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AB81887

Anti-CGRP antibody [4901]

5

(9 Reviews)

|

(224 Publications)

Anti-CGRP antibody [4901] (ab81887) is a mouse monoclonal antibody detecting CGRP in ICC/IF. Suitable for Human, Rat.

- Over 150 publications
- Trusted since 2009

View Alternative Names

Calc, Calca, Calcitonin gene-related peptide 1, CGRP1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-CGRP antibody [4901] (AB81887)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CGRP antibody [4901] (AB81887)

Immunofluorescent staining of CGRP (red) in cryopreserved DRG neurons grown on coverslips using ab81887 at 1/50 dilution. Green staining is PGP9.5. Yellow staining is the colocalization of CGRP and PGP9.5.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4901

Isotype

IgG2a

Carrier free

No

Reacts with

Human, Rat

Applications

ICC/IF

applications

Immunogen

Full Length Protein corresponding to Rat Calca aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P01256

Specificity

ab81887 is specific for Calcitonin Gene Related Peptide. It also recognizes rat beta CGRP and human alpha CGRP (10 fold less sensitivity compared to rat alpha CGRP).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Anti-CGRP antibody [4901] (ab81887) is a Mouse Monoclonal antibody and is validated for use in ICC/IF in human and rat samples.

Anti-CGRP antibody [4901] (ab81887) has been cited over 153 times in peer reviewed journals and is trusted by the scientific community.

Abcams high quality validation processes ensure Anti-CGRP antibody [4901] (ab81887) has high sensitivity and specificity.

Anti-CGRP antibody [4901] (ab81887) has 8 independent reviews from customers.

Anti-CGRP antibody [4901] (ab81887) specifically detects CGRP (UniProt ID: P01256; Molecular weight: 4kDa) and is sold in 100 uL selling sizes.

CGRP (Calcitonin Gene-Related Peptide) is a significant neuropeptide extensively studied in neuroscience. Its role is particularly noted in various neurodegenerative conditions, including Alzheimer's disease (AD). CGRP is involved in modulating inflammation and neuroprotection, making it a valuable marker for assessing neuroinflammatory responses. In AD, changes in CGRP expression can provide insights into the disease's progression and the associated inflammatory processes. This highlights CGRP's importance in understanding and potentially targeting neuroinflammation.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.5 Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CGRP or Calcitonin Gene-Related Peptide is a 37-amino acid neuropeptide with a molecular mass of approximately 3.8 kDa. This peptide exists mainly in two forms alpha-CGRP and beta-CGRP differing slightly in amino acid sequence. CGRP expresses in peripheral and central nervous systems with high levels in the dorsal root ganglia and thyroid gland. It also has a significant presence in the enteric nervous system and some segments of the cardiovascular system. Scientists note that CGRP acts as a potent vasodilator and plays a significant role in transducing pain signals.
Biological function summary

CGRP contributes to numerous physiological processes including blood flow regulation body temperature control pain transmission and neurogenic inflammation. It acts independently and does not substantially form part of larger protein complexes in its primary activities. Through binding to the CGRP receptor a complex made up of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) CGRP initiates downstream signaling that results in its various biological effects.

Pathways

Studies place CGRP within the neuropeptide signaling pathway and the vasodilation pathway. It significantly influences the cyclic AMP (cAMP) signaling pathway where it works collaboratively with other neuropeptides like substance P. The interaction with CLR and RAMP1 triggers the production of cAMP which enhances vasodilation and pain transmission processes in the body.

CGRP holds a notable connection to migraines and cardiovascular diseases. Elevated CGRP levels are observed in migraine sufferers and targeted treatments utilizing anti-CGRP antibodies have demonstrated efficacy in reducing migraine frequency. Additionally research links CGRP to blood pressure regulation abnormalities implicating its involvement in hypertension. Both conditions involve complex interactions with other proteins such as substance P and endothelial nitric oxide synthase (eNOS) which modulate vascular tone and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
See full target information Calca
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Publications (224)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8223 PubMed41022817

2025

Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models.

Applications

Unspecified application

Species

Unspecified reactive species

Tiantian Wang,Zejun Liang,Changyi Wang,Jiehao Chen,Yaru Ma,Sihan Chen,Dong Zhou,Zhen Hong

International journal of molecular sciences 26: PubMed40806609

2025

The Neuroregenerative Effects of IncobotulinumtoxinA (Inco/A) in a Nerve Lesion Model of the Rat.

Applications

Unspecified application

Species

Unspecified reactive species

Oscar Sánchez-Carranza,Wojciech Danysz,Klaus Fink,Maarten Ruitenberg,Andreas Gravius,Jens Nagel

Nature communications 16:7165 PubMed40759894

2025

Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking.

Applications

Unspecified application

Species

Unspecified reactive species

Man-Xiu Xie,Ren-Chun Lai,Yi-Bin Xiao,Shi-Yu Zuo,Hao Tang,Xian-Ying Cao,Jin-Kun Liu,Zi-Su Zhou,Shu-Hang Wang,Xiao-Fan Lu,Ying He,Yan Xie,Xiao-Long Zhang

eLife 13: PubMed40694497

2025

Metastatic small cell lung cancer arises from TP53/RB1-deficient and MYC overproduction hESC-derived PNECs.

Applications

Unspecified application

Species

Unspecified reactive species

Huanhuan Joyce Chen,Eric E Gardner,Yajas Shah,Kui Zhang,Abhimanyu Thakur,Chen Zhang,Olivier Elemento,Harold Varmus

Frontiers in endocrinology 16:1570685 PubMed40687591

2025

Jinkui Shenqi Pill accelerates osteoporotic fracture healing by promoting bone formation through neurosensory PGE2/EP4/p-CREB axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jihao Xi,Danqing Fu,Dan Xu,Ruhan Shen,Yan Zhao,Haoqiang Dai,Chenjie Xia,Peihong Zhou

Nature communications 16:6200 PubMed40615395

2025

Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.

Applications

Unspecified application

Species

Unspecified reactive species

Xianzhu Zhang,Wei Jiang,Xinyu Wu,Chang Xie,Yi Zhang,Liying Li,Yuqing Gu,Zihao Hu,Xinrang Zhai,Renjie Liang,Tao Zhang,Wei Sun,Jinchun Ye,Wei Wei,Xiaozhao Wang,Yi Hong,Shufang Zhang,Youzhi Cai,Xiaohui Zou,Yihe Hu,Hongwei Ouyang

Journal of neuroinflammation 22:161 PubMed40544251

2025

Pro-repair macrophages driven by CGRP rescue white matter integrity following intracerebral hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Huaping Huang,Yirui Kuang,Yang Chen,Yi Zhang,Jiayin Zhou,Xian Yu,Yonghe Zheng,Lingxin Cai,Wanglu Hu,Liansheng Gao,Haijian Wu,Hui Ling,Xiao Dong,Hang Zhou,Xiaobo Yu,Yucong Peng,Gao Chen,Xiaoyu Wang,Wei Yan

JOR spine 8:e70073 PubMed40386495

2025

An Extracellular Matrix Hydrogel Restores Disc Volume and Alleviates Axial Hypersensitivity in a Rat Model of Disc-Associated Pain.

Applications

Unspecified application

Species

Unspecified reactive species

David J Lillyman,Evie C Reddick,Kayla E Ney,Sydney M Caparaso,Rebecca A Wachs

CNS neuroscience & therapeutics 31:e70368 PubMed40202077

2025

TRPC4 Mediates Trigeminal Neuropathic Pain via Ca-ERK/P38-ATF2 Pathway in the Trigeminal Ganglion of Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xinlong Ke,Huajing Cai,Fangla Luo,Xing Zheng,Qian Hu,Youfa Zhou,Yongjie Wang,Xiangnan Zhang,Yeru Chen,Gang Chen

Nature 642:700-709 PubMed40175547

2025

A neural mechanism for learning from delayed postingestive feedback.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher A Zimmerman,Scott S Bolkan,Alejandro Pan-Vazquez,Bichan Wu,Emma F Keppler,Jordan B Meares-Garcia,Eartha Mae Guthman,Robert N Fetcho,Brenna McMannon,Junuk Lee,Austin T Hoag,Laura A Lynch,Sanjeev R Janarthanan,Juan F López Luna,Adrian G Bondy,Annegret L Falkner,Samuel S-H Wang,Ilana B Witten
View all publications
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Product promise

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