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AB195387

Anti-CGRP antibody

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(3 Publications)

Sheep Polyclonal CGRP-I antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Rat Calca.

View Alternative Names

Calc, Calca, Calcitonin gene-related peptide 1, CGRP1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB195387)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB195387)

Immunohistochemical analysis of paraffin-embedded Rat thoracolumbar spinal cord tissue labeling CGRP with ab195387 at 1/1000 dilution. Negative images of fluorescence detection procedure (Alexa488 conjugated secondary antibody).

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Rat Calca. The exact immunogen used to generate this antibody is proprietary information.

P01256

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "<p>Perfusion fixation is recommended if possible.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Precipitation Ammonium Sulphate
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CGRP or Calcitonin Gene-Related Peptide is a 37-amino acid neuropeptide with a molecular mass of approximately 3.8 kDa. This peptide exists mainly in two forms alpha-CGRP and beta-CGRP differing slightly in amino acid sequence. CGRP expresses in peripheral and central nervous systems with high levels in the dorsal root ganglia and thyroid gland. It also has a significant presence in the enteric nervous system and some segments of the cardiovascular system. Scientists note that CGRP acts as a potent vasodilator and plays a significant role in transducing pain signals.
Biological function summary

CGRP contributes to numerous physiological processes including blood flow regulation body temperature control pain transmission and neurogenic inflammation. It acts independently and does not substantially form part of larger protein complexes in its primary activities. Through binding to the CGRP receptor a complex made up of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) CGRP initiates downstream signaling that results in its various biological effects.

Pathways

Studies place CGRP within the neuropeptide signaling pathway and the vasodilation pathway. It significantly influences the cyclic AMP (cAMP) signaling pathway where it works collaboratively with other neuropeptides like substance P. The interaction with CLR and RAMP1 triggers the production of cAMP which enhances vasodilation and pain transmission processes in the body.

CGRP holds a notable connection to migraines and cardiovascular diseases. Elevated CGRP levels are observed in migraine sufferers and targeted treatments utilizing anti-CGRP antibodies have demonstrated efficacy in reducing migraine frequency. Additionally research links CGRP to blood pressure regulation abnormalities implicating its involvement in hypertension. Both conditions involve complex interactions with other proteins such as substance P and endothelial nitric oxide synthase (eNOS) which modulate vascular tone and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
See full target information Calca
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Clinical and experimental pharmacology & physiology 52:e70062 PubMed40776599

2025

PACAP Inhibits TNF-α- Induced Senescence in Primary Chondrocytes by SIRT3: An Implication in Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Xuewu Zhou,Kangquan Shou,Hao Yao

Journal of orthopaedic translation 52:97-115 PubMed40275883

2025

PDGF-BB improves cortical bone quality through restoring the osteogenic microenvironment in the steroid-associated osteonecrosis of rabbits.

Applications

Unspecified application

Species

Unspecified reactive species

Huijuan Cao,Keda Shi,Jing Long,Yanzhi Liu,Xiangbo Meng,Cuishan Huang,Jie Hao,Lingli Li,Yiqing Zhao,Tianluo Ye,Yuxiao Lai,Ling Qin,Xinluan Wang

Nature neuroscience 27:2326-2340 PubMed39496796

2024

Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation.

Applications

Unspecified application

Species

Unspecified reactive species

Huasheng Yu,Saad S Nagi,Dmitry Usoskin,Yizhou Hu,Jussi Kupari,Otmane Bouchatta,Hanying Yan,Suna Li Cranfill,Mayank Gautam,Yijing Su,You Lu,James Wymer,Max Glanz,Phillip Albrecht,Hongjun Song,Guo-Li Ming,Stephen Prouty,John Seykora,Hao Wu,Minghong Ma,Andrew Marshall,Frank L Rice,Mingyao Li,Håkan Olausson,Patrik Ernfors,Wenqin Luo
View all publications
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Product promise

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