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AB36001

Anti-CGRP antibody

5

(13 Reviews)

|

(197 Publications)

Anti-CGRP antibody (ab36001) is a goat polyclonal antibody detecting CGRP in IHC-P, IHC-Fr, ELISA. Suitable for Mouse, Rat.

- Over 140 publications
- Trusted since 2006

View Alternative Names

Calc, Calca, Calcitonin gene-related peptide 1, CGRP1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I

1 Images
ELISA - Anti-CGRP antibody (AB36001)
  • ELISA

Supplier Data

ELISA - Anti-CGRP antibody (AB36001)

Goat anti Rat Calcitonin Gene-Related Peptide ELISA. Synthetic Rat Calcitonin Gene-Related Peptide detected using ab36001 as the capture reagent and Donkey anti Sheep/Goat IgG : HRP as the detection reagent.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

ELISA, IHC-Fr, IHC-FoFr, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Antibody is thought to react with whole molecule (1-37) and 23-37 fragment (C term). Specifically visualises CGRP in brain cells.

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Reactivity data

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Product details

Product Specifications

Anti-CGRP antibody (ab36001) is a goat polyclonal antibody and is validated for use in ELISA, IHC-FoFr, IHC-Fr, IHC-P in mouse, rat samples.
Anti-CGRP antibody (ab36001) specifically detects CGRP (UniProt ID: P01256; Molecular weight: 14kDa) and is sold in 100 µL selling sizes.

Quality and Validation

Abcam's high quality validation processes ensure Anti-CGRP antibody (ab36001) has high sensitivity and specificity.
Anti-CGRP antibody (ab36001) has been cited over 144 times in peer reviewed journals and is trusted by the scientific community.
Anti-CGRP antibody (ab36001) has 12 independent reviews from customers.

Target Information

CGRP (Calcitonin Gene-Related Peptide) is a significant neuropeptide extensively studied in neuroscience. Its role is particularly noted in various neurodegenerative conditions, including Alzheimer's disease (AD). CGRP is involved in modulating inflammation and neuroprotection, making it a valuable marker for assessing neuroinflammatory responses. In AD, changes in CGRP expression can provide insights into the disease's progression and the associated inflammatory processes. This highlights CGRP's importance in understanding and potentially targeting neuroinflammation.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified Ig by Ammonium Sulphate fractionation.
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CGRP or Calcitonin Gene-Related Peptide is a 37-amino acid neuropeptide with a molecular mass of approximately 3.8 kDa. This peptide exists mainly in two forms alpha-CGRP and beta-CGRP differing slightly in amino acid sequence. CGRP expresses in peripheral and central nervous systems with high levels in the dorsal root ganglia and thyroid gland. It also has a significant presence in the enteric nervous system and some segments of the cardiovascular system. Scientists note that CGRP acts as a potent vasodilator and plays a significant role in transducing pain signals.
Biological function summary

CGRP contributes to numerous physiological processes including blood flow regulation body temperature control pain transmission and neurogenic inflammation. It acts independently and does not substantially form part of larger protein complexes in its primary activities. Through binding to the CGRP receptor a complex made up of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) CGRP initiates downstream signaling that results in its various biological effects.

Pathways

Studies place CGRP within the neuropeptide signaling pathway and the vasodilation pathway. It significantly influences the cyclic AMP (cAMP) signaling pathway where it works collaboratively with other neuropeptides like substance P. The interaction with CLR and RAMP1 triggers the production of cAMP which enhances vasodilation and pain transmission processes in the body.

CGRP holds a notable connection to migraines and cardiovascular diseases. Elevated CGRP levels are observed in migraine sufferers and targeted treatments utilizing anti-CGRP antibodies have demonstrated efficacy in reducing migraine frequency. Additionally research links CGRP to blood pressure regulation abnormalities implicating its involvement in hypertension. Both conditions involve complex interactions with other proteins such as substance P and endothelial nitric oxide synthase (eNOS) which modulate vascular tone and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
See full target information Calca
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Publications (197)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8223 PubMed41022817

2025

Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models.

Applications

Unspecified application

Species

Unspecified reactive species

Tiantian Wang,Zejun Liang,Changyi Wang,Jiehao Chen,Yaru Ma,Sihan Chen,Dong Zhou,Zhen Hong

Nature 646:1243-1253 PubMed40931078

2025

Functional synapses between neurons and small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Vignesh Sakthivelu,Anna Schmitt,Franka Odenthal,Kristiano Ndoci,Marian Touet,Ali H Shaib,Abdulla Chihab,Gulzar A Wani,Pascal Nieper,Griffin G Hartmann,Isabel Pintelon,Ilmars Kisis,Maike Boecker,Naja M Eckert,Manoela Iannicelli Caiaffa,Olta Ibruli,Julia Weber,Roman Maresch,Christina M Bebber,Ali Chitsaz,Anna Lütz,Mira Kim Alves Carpinteiro,Kaylee M Morris,Camilla A Franchino,Jonas Benz,Laura Pérez-Revuelta,Jorge A Soriano-Campos,Maxim A Huetzen,Jonas Goergens,Milica Jevtic,Hannah M Jahn-Kelleter,Hans Zempel,Aleksandra Placzek,Alexandru A Hennrich,Karl-Klaus Conzelmann,Hannah L Tumbrink,Pascal Hunold,Joerg Isensee,Lisa Werr,Felix Gaedke,Astrid Schauss,Marielle Minère,Marie Müller,Henning Fenselau,Yin Liu,Alena Heimsoeth,Gülce S Gülcüler Balta,Henning Walczak,Christian Frezza,Ron D Jachimowicz,Julie George,Marcel Schmiel,Johannes Brägelmann,Tim Hucho,Silvia von Karstedt,Martin Peifer,Alessandro Annibaldi,Robert Hänsel-Hertsch,Thorsten Persigehl,Holger Grüll,Martin L Sos,Guido Reifenberger,Matthias Fischer,Dirk Adriaensen,Reinhard Büttner,Julien Sage,Inge Brouns,Roland Rad,Roman K Thomas,Max Anstötz,Silvio O Rizzoli,Matteo Bergami,Elisa Motori,Hans Christian Reinhardt,Filippo Beleggia

Lower urinary tract symptoms 17:e70025 PubMed40761184

2025

Pharmacological Targeting of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels on Bladder Afferent Sensory Transmission.

Applications

Unspecified application

Species

Unspecified reactive species

Eric Woon,Jorge Villalobos Santeli,Jia Liu,Longtu Chen,George Kuchel,Bin Feng

Nature communications 16:5433 PubMed40595635

2025

SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity.

Applications

Unspecified application

Species

Unspecified reactive species

Li Liu,Zhigang Gao,Xueyuan Niu,Hong Yu,Xiaolong Xin,Yanlan Gu,Genghai Ma,Yan Gu,Yijun Liu,Sanhua Fang,Till Marquardt,Liang Wang

International journal of oral science 17:45 PubMed40461462

2025

Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Pa Reum Lee,Kihwan Lee,Ji Min Park,Shinae Kim,Seog Bae Oh

Science advances 11:eado6847 PubMed40267183

2025

Genetics- and age-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice.

Applications

Unspecified application

Species

Unspecified reactive species

Emanuel J Novais,Olivia K Ottone,Eric V Brown,Vedavathi Madhu,Victoria A Tran,Pranay Ramteke,Abhijit S Dighe,Michael D Solga,Alexandra Manchel,Angelo C Lepore,Makarand V Risbud

The journal of headache and pain 26:61 PubMed40155829

2025

Transcutaneous occipital nerve stimulation alleviated migraine related pain by regulating synaptic plasticity and CGRP expression in the periaqueductal gray of male rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yinglu Liu,Shengli Guo,Yang Li,Jingrui Mao,Xiaoxue Lin,Ruozhuo Liu,Dengfa Zhao,Zhao Dong,Shengyuan Yu,Xun Han

Nature communications 16:2975 PubMed40140393

2025

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Keunjung Heo,Tammy Szu-Yu Ho,Xiangsunze Zeng,Bruna Lenfers Turnes,Maryam Arab,Selwyn Jayakar,Kuchuan Chen,Georgios Kimourtzis,Michael C Condro,Elisa Fazzari,Xuan Song,J Tabitha Hees,Zhuqiu Xu,Xirui Chen,Lee B Barrett,Laura Perrault,Roshan Pandey,Kathleen Zhang,Aparna Bhaduri,Zhigang He,Harley I Kornblum,Jed Hubbs,Clifford J Woolf

eLife 13: PubMed40100256

2025

Pain persists in mice lacking both Substance P and CGRPα signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Donald Iain MacDonald,Monessha Jayabalan,Jonathan T Seaman,Rakshita Balaji,Alec R Nickolls,Alexander Theodore Chesler

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2417367 PubMed39965073

2025

GPR37 Activation Alleviates Bone Cancer Pain via the Inhibition of Osteoclastogenesis and Neuronal Hyperexcitability.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiyuan Wang,Yongfang Zhang,Ruichen Shu,Limei Yuan,Huifang Tu,Shengran Wang,Bo Ni,Yi-Fan Zhang,Changyu Jiang,Yuhui Luo,Yiqing Yin
View all publications
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