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AB238551

Anti-CHAD antibody

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(2 Publications)

Rabbit Polyclonal CHAD antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CHAD.

View Alternative Names

SLRR4A, CHAD, Chondroadherin, Cartilage leucine-rich protein

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHAD antibody (AB238551)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHAD antibody (AB238551)

Paraffin-embedded human adrenal gland tissue stained for CHAD with ab238551 at a 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CHAD.

O15335

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CHAD known as Chondroadherin is a protein that plays a mechanical role in cartilage structure. It has a molecular mass of approximately 38 kDa. You can find CHAD expressed mainly in cartilage tissues where it contributes to maintaining the integrity of the extracellular matrix. The protein interacts with other matrix components allowing it to help stabilize cartilage structure and function.
Biological function summary

CHAD takes part in cell adhesion and interaction within cartilage tissue. It does not typically form a complex with other proteins instead functioning by binding to collagen fibrils and integrins. This binding action promotes the linkage between cells and the extracellular matrix important for maintaining healthy cartilage. CHAD's role in cell adhesion underlines its importance in tissue-specific functions and structural support.

Pathways

CHAD functions within the cartilage development pathway specifically contributing to extracellular matrix organization. It interacts with proteins like collagen and integrins strengthening structural network essential for cartilage durability. Another relevant pathway is the integrin signaling pathway where CHAD influences cellular responses to mechanical stimuli aligning its role with tissue maintenance and repair processes.

CHAD relates closely to osteoarthritis a condition characterized by the degeneration of cartilage. The protein's interaction with collagen and integrins might influence cartilage resilience potentially affecting the progression of osteoarthritis. Moreover CHAD's presence and function also connect it to cartilage-related disorders encompassing its relationship with collagen and integrins both vital in maintaining cartilage health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).
See full target information CHAD
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:33763 PubMed41028834

2025

Icariin inhibits proliferation and migration of VSMCs via LncRNA H19 competitively binding to HuR.

Applications

Unspecified application

Species

Unspecified reactive species

Yibing Zhang,Peng Huang,Min Li,Zhimin Fan

Aging cell 23:e14320 PubMed39158018

2024

Single-cell RNA sequencing reveals the CRTAC1 population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1 macrophage.

Applications

Unspecified application

Species

Unspecified reactive species

Yulong Tang,Dachun Zhuo,Yuexin Yu,Weilin Pu,Yanyun Ma,Yuting Zhang,Yan Huang,Qing Zhang,Kunhai Tang,Chen Meng,Di Yang,Lu Bai,Dongyi He,Li Jin,Hejian Zou,Huji Xu,Qi Zhu,Jiucun Wang,Yuanyuan Chen,Jing Liu
View all publications
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