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AB198233

Anti-CHDH antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal CHDH antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Choline dehydrogenase, mitochondrial.

View Alternative Names

CDH, CHD, CHDH

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHDH antibody - C-terminal (AB198233)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHDH antibody - C-terminal (AB198233)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling CHDH with ab198233 at 1/20 dilution.

Western blot - Anti-CHDH antibody - C-terminal (AB198233)
  • WB

Supplier Data

Western blot - Anti-CHDH antibody - C-terminal (AB198233)

Gel : 10%SDS-PAGE

All lanes:

Western blot - Anti-CHDH antibody - C-terminal (ab198233) at 1/400 dilution

Lane 1:

231 cell lysate at 40 µg

Lane 2:

Mouse kidney tissue lysate at 40 µg

Predicted band size: 65 kDa

false

Exposure time: 20s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Choline dehydrogenase, mitochondrial. The exact immunogen used to generate this antibody is proprietary information.

Q8NE62

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CHDH also known as choline dehydrogenase functions mechanically as an enzyme that plays an important role in choline metabolism. This enzyme exhibits a molecular mass of approximately 61 kDa. It catalyzes the oxidation of choline to betaine aldehyde converting it further to glycine betaine which influences osmotic stress adaptation. CHDH shows strong expression in kidney and liver tissues indicating its role in these organs.
Biological function summary

The process facilitated by CHDH is essential for synthesizing glycine betaine a critical osmolyte that helps cells combat osmotic stress by stabilizing proteins and cell membranes. CHDH does not operate within a complex but is involved directly as a part of individual reactions leading to glycine betaine formation. This biological function supports cellular tolerance to high salinity and dehydration conditions.

Pathways

Choline metabolism and glycine serine and threonine metabolism involve CHDH as a significant component. Choline metabolism intimately connects with one-carbon metabolism where nutrients like folate integrate through various conversions. Within these pathways CHDH interacts closely with betaine-aldehyde dehydrogenase another enzyme that completes the conversion of choline into glycine betaine.

CHDH associates with conditions such as prostate cancer and liver disease. Aberrant expression or mutations in CHDH can contribute to an imbalance in osmoprotectant levels affecting cellular function. Its association with the folate cycle also links it to homocysteine levels where disruptions might result in increased risk for cardiovascular disease interacting indirectly with proteins like methylene tetrahydrofolate reductase (MTHFR) which influences homocysteine metabolism.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Choline dehydrogenase, mitochondrial
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Publications (1)

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Molecular medicine reports 22:2263-2272 PubMed32705251

2020

Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Ou Lan,He-Xiao Wang,Rui-Qun Qi,Yuan-Yuan Xu,Ya-Jie Yu,Yang Yang,Hao Guo,Xing-Hua Gao,Long Geng
View all publications
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Product promise

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