Mouse Monoclonal Choriogonadotropin subunit beta antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CGB3.
Preservative: 0.09% Sodium azide
Constituents: PBS
| ELISA | WB | IHC-P | |
|---|---|---|---|
| Human | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
CGB, CGB5, CGB8, CGB3, Choriogonadotropin subunit beta 3, Choriogonadotropin subunit beta, Chorionic gonadotropin chain beta, CG-beta
Mouse Monoclonal Choriogonadotropin subunit beta antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CGB3.
Preservative: 0.09% Sodium azide
Constituents: PBS
Ab11389 shows strong reaction in RIA with hCG and beta hCG with some reactivity on hLH (12%) and beta hLH (34%).
No reaction with hFSH, hTSH, alpha hCG and alpha hLH.
Affinity constant = 1.6 x 109m (Ka).
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Choriogonadotropin subunit beta 3 often known as beta hCG or hCG 2 is a vital protein component of the hormone human chorionic gonadotropin (hCG). This protein which has a mass of around 22-25 kDa is necessary for the reproductive process. Primarily expressed in the placental trophoblastic cells chorion and testicular germ cell tumors choriogonadotropin beta subunit plays an instrumental role in pregnancy maintenance and has become a useful marker in clinical diagnostics particularly in prenatal screenings and cancer assays.
HCG 2 stimulates corpus luteum maintenance during early pregnancy promoting progesterone production which is essential for uterine lining support. The choriogonadotropin beta subunit forms a functional heterodimer with the alpha subunit sharing similarity with other glycoprotein hormone structures like luteinizing hormone (LH). The intact heterodimer acts at the LH/CG receptor revealing its bioactivity in reproductive tissues.
The choriogonadotropin beta subunit participates in the reproductive hormone signaling pathways particularly in facilitating reproductive processes. It is closely related to proteins such as luteinizing hormone sharing pathways involved in gonadal steroidogenesis. This connection ensures the regulation of steroid hormones critical for reproduction and sexual development.
Choriogonadotropin beta subunit serves as a marker for conditions like gestational trophoblastic disease and testicular cancer. Abnormal levels of beta hCG indicate pathological states with links to ovarian and testicular tumor markers. Its role alongside other proteins like alpha-fetoprotein (AFP) and lactate dehydrogenase (LDH) aids in the diagnosis and monitoring of these malignancies.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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