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AB11389

Anti-Choriogonadotropin subunit beta 3 antibody [INN-hCG-22]

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(2 Publications)

Mouse Monoclonal Choriogonadotropin subunit beta antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CGB3.

View Alternative Names

CGB, CGB5, CGB8, CGB3, Choriogonadotropin subunit beta 3, Choriogonadotropin subunit beta, Chorionic gonadotropin chain beta, CG-beta

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

INN-hCG-22

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, ELISA, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CGB3.

P0DN86

Specificity

Ab11389 shows strong reaction in RIA with hCG and beta hCG with some reactivity on hLH (12%) and beta hLH (34%). No reaction with hFSH, hTSH, alpha hCG and alpha hLH. Affinity constant = 1.6 x 109m (Ka).

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Choriogonadotropin subunit beta 3 often known as beta hCG or hCG 2 is a vital protein component of the hormone human chorionic gonadotropin (hCG). This protein which has a mass of around 22-25 kDa is necessary for the reproductive process. Primarily expressed in the placental trophoblastic cells chorion and testicular germ cell tumors choriogonadotropin beta subunit plays an instrumental role in pregnancy maintenance and has become a useful marker in clinical diagnostics particularly in prenatal screenings and cancer assays.
Biological function summary

HCG 2 stimulates corpus luteum maintenance during early pregnancy promoting progesterone production which is essential for uterine lining support. The choriogonadotropin beta subunit forms a functional heterodimer with the alpha subunit sharing similarity with other glycoprotein hormone structures like luteinizing hormone (LH). The intact heterodimer acts at the LH/CG receptor revealing its bioactivity in reproductive tissues.

Pathways

The choriogonadotropin beta subunit participates in the reproductive hormone signaling pathways particularly in facilitating reproductive processes. It is closely related to proteins such as luteinizing hormone sharing pathways involved in gonadal steroidogenesis. This connection ensures the regulation of steroid hormones critical for reproduction and sexual development.

Choriogonadotropin beta subunit serves as a marker for conditions like gestational trophoblastic disease and testicular cancer. Abnormal levels of beta hCG indicate pathological states with links to ovarian and testicular tumor markers. Its role alongside other proteins like alpha-fetoprotein (AFP) and lactate dehydrogenase (LDH) aids in the diagnosis and monitoring of these malignancies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
See full target information CGB3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

PloS one 19:e0295673 PubMed38394285

2024

Generation of epitope-specific hCG aptamers through a novel targeted selection approach.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren Ferreira,Shane Patrick Flanagan,Ronen Fogel,Janice Leigh Limson

Cancer medicine 11:968-982 PubMed35044085

2022

Glycan signatures for the identification of cisplatin-resistant testicular cancer cell lines: Specific glycoprofiling of human chorionic gonadotropin (hCG).

Applications

Unspecified application

Species

Unspecified reactive species

Michal Hires,Eduard Jane,Katarina Kalavska,Michal Chovanec,Michal Mego,Peter Kasak,Tomas Bertok,Jan Tkac
View all publications
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Product promise

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