Rabbit Polyclonal CGB7 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human Choriogonadotropin subunit beta 7.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Choriogonadotropin subunit beta 7. The exact immunogen used to generate this antibody is proprietary information. Database link P0DN87
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Expected |
| Mouse | Expected | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Target data
Function
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Additional Targets
Choriogonadotropin subunit beta 7
Alternative names
Choriogonadotropin subunit beta 7, CGB7
Recommended products
Rabbit Polyclonal CGB7 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human Choriogonadotropin subunit beta 7.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Choriogonadotropin subunit beta 7. The exact immunogen used to generate this antibody is proprietary information. Database link P0DN87
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Chorionic Gonadotropin often called hCG is a glycoprotein hormone essential for reproductive processes. With a molecular mass of about 37 kDa it consists of an alpha and beta subunit. It shares the alpha subunit with other pituitary glycoprotein hormones but the beta subunit is distinct and gives hCG its unique biological activity. The hormone is mainly expressed in the placenta during pregnancy supporting corpus luteum function and stimulating the production of progesterone. This expression plays a primary role in maintaining the early stages of pregnancy.
- Biological function summary
HCG promotes fetal development and modulates the maternal immune response to support a successful pregnancy. It acts as a signal between the developing placenta and maternal cells. Furthermore hCG belongs to a hormone-receptor complex binding to the luteinizing hormone/chorionic gonadotropin receptor (LH/CG receptor) on target tissues. This interaction triggers intracellular pathways that are vital for maintaining pregnancy dynamics.
- Pathways
HCG is integral in reproductive and endocrine signaling pathways. Participating in the cAMP-dependent signaling pathway it activates adenylate cyclase after binding to its receptor increasing cyclic AMP levels and protein kinase A (PKA) activity. hCG is also related to luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as they share the alpha subunit and interact with similar receptors facilitating communication within reproductive hormonal pathways.
- Associated diseases and disorders
HCG serves as a biomarker for certain trophoblastic diseases and testicular cancer. Elevated levels of hCG may indicate gestational trophoblastic disease while abnormal hCG patterns can be associated with testicular cancer in males. Additionally hCG levels relate to disorders like hyperemesis gravidarum a severe form of nausea during pregnancy. Its interactions with proteins such as the LH/CG receptor play a part in these disease contexts offering diagnostic and potential therapeutic insights.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-Chorionic Gonadotropin antibody (ab133210)
All lanes: Western blot - Anti-Chorionic Gonadotropin antibody (ab133210) at 1/500 dilution
Lane 1: NIH-3T3 cell extracts
Lane 2: NIH-3T3 cell extracts with Synthesized peptide
Predicted band size: 18 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Chorionic Gonadotropin antibody (ab133210)
ab133210, at 10 µg/ml, staining Chorionic Gonadotropin in Formalin-fixed, Paraffin-embedded Human placenta trophoblast tissue by Immunohistochemistry.
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