Rabbit Polyclonal CHREBP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human MLXIPL aa 800 to C-terminus.
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Publications
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- mBio 13:e00435222022IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGloria Griffante,Weronika Hewelt-Belka,Camilla Albano,Francesca Gugliesi,Selina Pasquero,Sergio Fernando Castillo Pacheco,Greta Bajetto,Paolo Ettore Porporato,Erica Mina,Marta Vallino,Christian Krapp,Martin Roelsgaard Jakobsen,John Purdy,Jens von Einem,Santo Landolfo,Valentina Dell'Oste,Matteo BiolattiPubMed 35420480
- International journal of molecular sciences 22:2021Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAleksandra Owczarek,Katarzyna B Gieczewska,Robert Jarzyna,Zuzanna Frydzinska,Katarzyna WiniarskaPubMed 34948094
- Nature metabolism 3:923-9392021Intestinal MYC modulates obesity-related metabolic dysfunction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuhong Luo,Shoumei Yang,Xuan Wu,Shogo Takahashi,Lulu Sun,Jie Cai,Kristopher W Krausz,Xiaozhen Guo,Henrique B Dias,Oksana Gavrilova,Cen Xie,Changtao Jiang,Weiwei Liu,Frank J GonzalezPubMed 34211180
- Food & nutrition research 65:2021Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeilan Xue,Hui Liang,Zhitong Zhou,Ying Liu,Xinjia He,Zheng Zhang,Ting Sun,Jia Yang,Yimin Qin,Kunpeng QinPubMed 33994911
- Cell death discovery 7:142021Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao Dong,Fan Wang,Chuan Liu,Jing Ling,Xuebing Jia,Feifei Shen,Ning Yang,Sibo Zhu,Lin Zhong,Qi LiPubMed 33462196
- Molecular medicine reports 22:2174-21822020Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Zhang et. al.PubMed 32705195
- Aging 12:11004-110242020Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHongrui Zhan et. al.PubMed 32518215
- American journal of physiology. Endocrinology and 319:E133-E1452020Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMary Courtney Moore et. al.PubMed 32459527
- Journal of cellular physiology 235:9819-98332020Long noncoding RNA CCAT1 inhibits miR-613 to promote nonalcoholic fatty liver disease via increasing LXRα transcription.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFeizhou Huang,Huaizheng Liu,Zhao Lei,Zhenzhou Li,Tianyi Zhang,Mingshi Yang,Kefu Zhou,Chuanzheng SunPubMed 32413192
- Endocrine journal 67:335-3452019Expression and pathophysiological significance of carbohydrate response element binding protein (ChREBP) in the renal tubules of diabetic kidney.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSusumu Suzuki,Atsushi Yokoyama,Erika Noro,Satoshi Aoki,Kyoko Shimizu,Hiroki Shimada,Akira SugawaraPubMed 31813922
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human MLXIPL aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP71
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Expected | Tested | Expected |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity).
Alternative names
BHLHD14, MIO, WBSCR14, MLXIPL, Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, Williams-Beuren syndrome chromosomal region 14 protein, bHLHd14, WS-bHLH
Recommended products
Rabbit Polyclonal CHREBP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human MLXIPL aa 800 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human MLXIPL aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP71
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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3 product images
Western blot - Anti-CHREBP antibody (ab92809)
5-10 second film exposure
All lanes: Western blot - Anti-CHREBP antibody (ab92809)
All lanes: human hepatocyte lysate at 20 µg
Predicted band size: 93 kDa
Immunocytochemistry/ Immunofluorescence - Anti-CHREBP antibody (ab92809)
anti CHREBP staining CHREBP in human hepatocyte by Immunofluorescence. Overlay staining of ChREBP (rhodamine red) and DAPI nuclear staining (blue).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHREBP antibody (ab92809)
Immunohistochemistry analysis of mouse liver labeling CHREBP with ab92809. DAB with hematoxylin counterstain.
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