AB92809

Anti-CHREBP antibody

Name: Anti-CHREBP antibody (ab92809) | Abcam
Brand: Abcam Limited
SKU: AB92809
Price: 535 USD
Availability: InStock

(1 Review)

(20 Publications)

Rabbit Polyclonal CHREBP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 20 publications. Immunogen corresponding to Synthetic Peptide within Human MLXIPL aa 800 to C-terminus.

View Alternative Names

BHLHD14, MIO, WBSCR14, MLXIPL, Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, Williams-Beuren syndrome chromosomal region 14 protein, bHLHd14, WS-bHLH

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHREBP antibody (AB92809)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHREBP antibody (AB92809)

anti CHREBP staining CHREBP in human colon epithelium (40X) by immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-CHREBP antibody (AB92809)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CHREBP antibody (AB92809)

anti CHREBP staining CHREBP in human hepatocyte by Immunofluorescence. Overlay staining of ChREBP (rhodamine red) and DAPI nuclear staining (blue).

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHREBP antibody (AB92809)

Immunohistochemistry analysis of mouse liver labeling CHREBP with ab92809. DAB with hematoxylin counterstain.

Unknown

Western blot - Anti-CHREBP antibody (AB92809)

5-10 second film exposure

All lanes:

Western blot - Anti-CHREBP antibody (ab92809)

All lanes:

human hepatocyte lysate at 20 µg

Predicted band size: 93 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human MLXIPL aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NP71

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.01% Sodium azide Constituents: Tris citrate/phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Glucose-responsive transcription activator that regulates fatty acid synthesis and glycolysis. Key determinant of systemic insulin sensitivity and glucose homeostasis. Important for the expression of fatty acid synthetic enzymes, including PC/Pcx, APOC4/Acl, ACACA/Acc1 and FASN/Fas (By similarity). Important for glucose-induced expression of L-type pyruvate kinase/PKLR (By similarity). Binds to the canonical and non-canonical E box DNA sequences 5'-CACGTG-3' and 5'-CACGCG-3' (By similarity). May also act as a transcriptional repressor (By similarity).

See full target information MLXIPL

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Publications (20)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 25:25 PubMed39871246

2025

DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Wang,Shen Luo,Yue Yin,Yang Liu,Xiaomei Sun,Ling Qiu,Xin Wu

Molecular medicine (Cambridge, Mass.) 30:229 PubMed39580381

2024

Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced β-cell damage.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Gong,Meilin Wei,Xiaopei Cao,Changliu Xu,Jiewen Jin,Ling Pei,Yanbing Li,Haipeng Xiao,Liting Wu

Journal of diabetes investigation 15:1177-1190 PubMed38874179

2024

Imeglimin enhances glucagon secretion through an indirect mechanism and improves fatty liver in high-fat, high-sucrose diet-fed mice.

Applications

Unspecified application

Species

Unspecified reactive species

Osamu Kikuchi,Yuichi Ikeuchi,Masaki Kobayashi,Yoko Tabei,Hiromi Yokota-Hashimoto,Tadahiro Kitamura

iScience 26:107727 PubMed37674987

2023

Characterization of an steatosis model simulating activated lipogenesis in MAFLD patients.

Applications

Unspecified application

Species

Unspecified reactive species

Woonghee Kim,Mengzhen Li,Han Jin,Hong Yang,Hasan Türkez,Mathias Uhlén,Cheng Zhang,Adil Mardinoglu

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 164:114945 PubMed37263166

2023

Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Laetitia Dore,Erwann Durand,Béatrice Bonafos,Jatuporn Chaiyut,Laurent Vaysse,Siriluck Liengprayoon,Sylvie Gaillet,Laurence Pessemesse,Karen Lambert,Christelle Bertrand-Gaday,Charles Coudray,Ariane Sultan,François Casas,Christine Feillet-Coudray

BMC cancer 23:176 PubMed36809979

2023

MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Chang,Chang Tian,Yuanyuan Jia,Yu Cai,Pu Yan

The Journal of nutritional biochemistry 112:109216 PubMed36372312

2022

9-PAHPA long term intake in DIO and db/db mice ameliorates insulin sensitivity but has few effects on obesity and associated metabolic disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Béatrice Bonafos,Antonio J Cortés-Espinar,Laurence Balas,Laurence Pessemesse,Karen Lambert,Melha Benlebna,Sylvie Gaillet,François Pelletier,Pierre Delobel,Javier Ávila-Román,Miquel Mulero Abellán,Christelle Bertrand-Gaday,Thierry Durand,Charles Coudray,François Casas,Christine Feillet-Coudray

mBio 13:e0043522 PubMed35420480

2022

IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Gloria Griffante,Weronika Hewelt-Belka,Camilla Albano,Francesca Gugliesi,Selina Pasquero,Sergio Fernando Castillo Pacheco,Greta Bajetto,Paolo Ettore Porporato,Erica Mina,Marta Vallino,Christian Krapp,Martin Roelsgaard Jakobsen,John Purdy,Jens von Einem,Santo Landolfo,Valentina Dell'Oste,Matteo Biolatti

International journal of molecular sciences 22: PubMed34948094

2021

Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandra Owczarek,Katarzyna B Gieczewska,Robert Jarzyna,Zuzanna Frydzinska,Katarzyna Winiarska

Nature metabolism 3:923-939 PubMed34211180

2021

Intestinal MYC modulates obesity-related metabolic dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhong Luo,Shoumei Yang,Xuan Wu,Shogo Takahashi,Lulu Sun,Jie Cai,Kristopher W Krausz,Xiaozhen Guo,Henrique B Dias,Oksana Gavrilova,Cen Xie,Changtao Jiang,Weiwei Liu,Frank J Gonzalez

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CHREBP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHREBP antibody (AB92809)

Immunocytochemistry/ Immunofluorescence - Anti-CHREBP antibody (AB92809)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHREBP antibody (AB92809)

Western blot - Anti-CHREBP antibody (AB92809)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (20)

Product promise