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AB150354

Anti-Chromogranin B antibody [EPR9568]

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(2 Publications)

Rabbit Recombinant Monoclonal Chromogranin B antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.

View Alternative Names

SCG1, CHGB, Secretogranin-1, Chromogranin-B, Secretogranin I, CgB, SgI

1 Images
Western blot - Anti-Chromogranin B antibody [EPR9568] (AB150354)
  • WB

Unknown

Western blot - Anti-Chromogranin B antibody [EPR9568] (AB150354)

All lanes:

Western blot - Anti-Chromogranin B antibody [EPR9568] (ab150354) at 1/1000 dilution

Lane 1:

Fetal brain lysate at 10 µg

Lane 2:

HeLa lysate at 10 µg

Lane 3:

C6 lysate at 10 µg

Lane 4:

NIH3T3 lysate at 10 µg

Lane 5:

Raw 264.7 lysate at 10 µg

Lane 6:

Fetal kidney lysate at 10 µg

Predicted band size: 78 kDa

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  • Carrier free

    Anti-Chromogranin B antibody [EPR9568] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9568

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Chromogranin B also known as secretogranin I is a member of the granin protein family and is sometimes referred to alongside chromogranin A and other chromogranins. Chromogranin B is a secretory protein with a known mass of approximately 80 kDa. This protein expresses primarily in neuroendocrine cells where it localizes to the secretory granules. Chromogranins including chromogranin B play a role in the formation and stabilization of secretory granules important for storing and releasing peptide hormones and neuropeptides.
Biological function summary

Chromogranin B functions beyond merely being a constituent of secretory granules. It plays a role in the regulation of neuroendocrine secretion processes and interacts with the chromogranin core complex. This complex is involved in the packaging and sorting of peptides and hormones within cells. Chromogranin B also exhibits roles in modulating calcium-binding dynamics which is critical for cellular signaling and hormone secretion. Unlike chromogranin A chromogranin B is less abundant but still significant for cellular processes.

Pathways

Chromogranin B prominently aligns with the secretory pathway associated with neuroendocrine tissues. This pathway involves several proteins like chromogranin A that often work alongside chromogranin B to influence hormone release. Another pathway where chromogranin B plays a role involves the regulation of catecholamine release vital for stress responses. This particular involvement with catecholamines links chromogranin B to its role in neurotransmitter regulation.

Chromogranin B shows an association with conditions such as neuroendocrine tumors and hypertension. In neuroendocrine tumors chromogranin B can serve as a biomarker since its levels often elevate in these conditions akin to chromogranin A. Hypertension studies suggest connections between chromogranin B and the dysregulation of catecholamine release impacting blood pressure regulation. Understanding the role of chromogranin B and its related proteins can help in diagnosing and potentially targeting these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
See full target information CHGB
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neurology 13:1056947 PubMed36582614

2022

Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyu Feng,Hua Lin,Yue Zhao,Yongyan Yang,Xiaoli Zhuang,Yang Yu,Yonghao Yu

Scientific reports 12:8758 PubMed35610292

2022

Activation of Gαq sequesters specific transcripts into Ago2 particles.

Applications

Unspecified application

Species

Unspecified reactive species

Lela Jackson,Madison Rennie,Alison Poussaint,Suzanne Scarlata
View all publications
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Product promise

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