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AB281004

Anti-Chromogranin C/SGII antibody [EPR23876-62] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal Chromogranin C/SGII antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

View Alternative Names

CHGC, SCG2, Secretogranin-2, Chromogranin-C, Secretogranin II, SgII

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Sandwich ELISA - Anti-Chromogranin C/SGII antibody [EPR23876-62] - BSA and Azide free (Detector) (AB281004)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Chromogranin C/SGII antibody [EPR23876-62] - BSA and Azide free (Detector) (AB281004)

Example of Human Chromogranin C/SGII standard curve. Background-subtracted data values (mean +/- SD) are graphed.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR23876-62

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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AB304940

Human Chromogranin C/SGII ELISA Kit

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We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Product details

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Chromogranin C also known as secretogranin II (SGII) is a member of the granin family and weighs approximately 68 kDa. This protein is mainly located within the dense core secretory granules of endocrine and neuronal cells. It plays a mechanical role in the storage and release of peptide hormones and neurotransmitters. Chromogranin C is found in various regions of the brain adrenal medulla and in the pituitary gland reflecting its involvement in the neuroendocrine system.
Biological function summary

This protein functions in the regulation of peptide hormone secretion and is part of a complex with other granin proteins such as Chromogranin A. It modulates the granule's environment by affecting the pH and ionic composition which influences the storage and release of hormones and neurotransmitters. Chromogranin C participates in the production of biologically active peptides after proteolytic processing playing roles in the modulation of endocrine and neuronal activities.

Pathways

Chromogranin C connects to the neuroendocrine signaling pathways and regulated secretory pathway. Within these pathways it interacts with other proteins such as the prohormone convertases and furin which handle peptide precursors' cleavage into active hormones and neurotransmitters. This procession is important for maintaining cellular communication and response mechanisms linking Chromogranin C to cellular signaling and biochemical processes that control physiological homeostasis and stress responses.

Chromogranin C correlates with neurodegenerative diseases like Alzheimer's disease and psychiatric disorders such as depression. These connections arise through its relationship with amyloid precursor protein in Alzheimer's and alterations in serotonergic systems in depression. The expression levels and processing of Chromogranin C may serve as a biomarker for these diseases highlighting its potential role in the pathogenesis and progression of neuro-psychiatric conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
See full target information SCG2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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