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AB10881

Anti-Cig2 antibody [CIG 3A11/5]

5

(1 Review)

|

(4 Publications)

Mouse Monoclonal CG22 antibody. Suitable for IP, ELISA and reacts with Schizosaccharomyces pombe samples. Cited in 4 publications.

View Alternative Names

cyc17, SPAPB2B4.03, cig2, G2/mitotic-specific cyclin cig2

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CIG 3A11/5

Isotype

IgG1

Carrier free

No

Reacts with

Schizosaccharomyces pombe

Applications

IP, ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Schizosaccharomyces pombe": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cig2 also known as Cdc13 cyclin is a protein with a mass of around 60 kDa. It functions mechanically as an important regulator of the cell cycle particularly in the initiation of DNA replication. Cig2 is part of a family of cyclins and is expressed predominantly in fission yeast Schizosaccharomyces pombe. The protein forms a complex with Cdc2 to regulate the S phase entry of the cell cycle.
Biological function summary

Cig2 helps control the timing for the initiation of DNA replication contributing to genome stability. Cig2 interacts with Cdc2 kinase to form an active complex that facilitates cell cycle progression ensuring accurate replication processes. The coordination within this complex allows the cell to transition from the G1 phase to S phase monitoring and controlling the replication machinery.

Pathways

Cig2 holds a significant role within the cell cycle regulatory mechanisms. It participates in the regulation of the S phase entry within the well-known cyclin-dependent kinase pathway. Cig2 primarily interacts with Cdc2 but it also influences the activity of other related cyclins such as Cig1 which together contribute to the control of cellular division and replication. This cyclin-dependent regulation ensures a tightly controlled cell cycle progression.

Abnormalities in Cyclin-dependent kinase pathways involving Cig2 might lead to replication stress contributing to oncogenic transformations. Although Cig2 itself is studied mainly in yeast it provides insights into cyclin mechanisms relevant to cancer development in higher organisms. Furthermore disruptions in the regulatory interplay involving Cig2 and Cdc2 can manifest in misregulated cell growth leading to proliferative disorders. Understanding the interactions between these proteins is valuable for developing potential therapeutic targets for cancer treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.
See full target information cig2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature 607:381-386 PubMed35676478

2022

Core control principles of the eukaryotic cell cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Souradeep Basu,Jessica Greenwood,Andrew W Jones,Paul Nurse

Molecular and cellular biology 29:4959-70 PubMed19596787

2009

A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoqing Chu,Majid Eshaghi,Suk Yean Poon,Jianhua Liu

Molecular biology of the cell 18:1756-67 PubMed17332498

2007

Modulation of cell cycle-specific gene expressions at the onset of S phase arrest contributes to the robust DNA replication checkpoint response in fission yeast.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoqing Chu,Juntao Li,Majid Eshaghi,Xu Peng,R Krishna M Karuturi,Jianhua Liu

Molecular cell 6:1377-87 PubMed11163211

2001

The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases.

Applications

Unspecified application

Species

Unspecified reactive species

H Yamano,K Kitamura,K Kominami,A Lehmann,S Katayama,T Hunt,T Toda
View all publications
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