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AB235913

Anti-Cip4 antibody

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(1 Publication)

Rabbit Polyclonal CIP4 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIP10 aa 250 to C-terminus.

View Alternative Names

CIP4, STOT, STP, TRIP10, Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, Thyroid receptor-interacting protein 10, hSTP, TR-interacting protein 10, TRIP-10

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-Cip4 antibody (AB235913)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Cip4 antibody (AB235913)

PC-3 (human prostate adenocarcinoma cell line) cells stained for Cip4 using ab235913 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cip4 antibody (AB235913)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cip4 antibody (AB235913)

Paraffin-embedded human pancreas tissue stained for Cip4 with ab235913 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cip4 antibody (AB235913)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cip4 antibody (AB235913)

Paraffin-embedded human skeletal muscle tissue stained for Cip4 with ab235913 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TRIP10 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q15642

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cip4 also known as Cdc42-interacting protein 4 is a member of the F-BAR family and is involved in cellular processes related to actin dynamics. It has a molecular mass of approximately 70 kDa. Cip4 interacts with Cdc42 a small GTPase to facilitate membrane bending and invagination important for endocytosis and membrane trafficking. This protein is expressed in a variety of tissues including the brain heart and liver reflecting its broad functional significance across different cell types.
Biological function summary

Cip4 plays an essential role in linking membranes to the actin cytoskeleton. It is part of a complex with other proteins like Toca-1 and N-WASP which are important for actin polymerization. This function supports cellular morphogenesis and migration by organizing the actin filaments in response to external signals. Cip4 also contributes to the regulation of cell shape and motility aiding in processes such as development and immune responses by modulating membrane-associated actin assembly.

Pathways

Cip4 participates in pathways including the Cdc42 signaling pathway and endocytosis. In the Cdc42 signaling pathway Cip4 works with proteins like N-WASP and dynamin to facilitate membrane remodeling and cytoskeletal rearrangements impacting processes like cell division and signal transduction. Its involvement in endocytosis influences cargo uptake and intracellular transport linking it to dynamin-dependent endocytic pathways critical for nutrient uptake and receptor internalization.

Cip4 is associated with certain cancers and neurological disorders. Its dysregulation can contribute to tumor progression often involving interactions with proteins like Cdc42 and N-WASP that promote changes in cell adhesion and motility. Additionally abnormalities in Cip4 expression or function may lead to disrupted cell signaling in neurological disorders impacting processes essential for brain development and function. Understanding Cip4's role in these contexts provides insights into potential therapeutic targets for treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
See full target information TRIP10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cells 11: PubMed36359879

2022

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Di Giorgio,Antonio Lupia,Silvia Marchianò,Martina Bordoni,Rachele Bellini,Carmen Massa,Ginevra Urbani,Rosalinda Roselli,Federica Moraca,Valentina Sepe,Bruno Catalanotti,Elva Morretta,Maria Chiara Monti,Michele Biagioli,Eleonora Distrutti,Angela Zampella,Stefano Fiorucci
View all publications
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Product promise

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