JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB106230

Anti-CIRP antibody

5

(2 Reviews)

|

(12 Publications)

Goat Polyclonal CIRP antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human CIRBP aa 150 to C-terminus.

View Alternative Names

A18HNRNP, CIRP, CIRBP, Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP

1 Images
Western blot - Anti-CIRP antibody (AB106230)
  • WB

Unknown

Western blot - Anti-CIRP antibody (AB106230)

All lanes:

Western blot - Anti-CIRP antibody (ab106230) at 0.01 µg/mL

All lanes:

mouse testis lysate in RIPA buffer at 35 µg

Predicted band size: 18 kDa

true

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human, Rat

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CIRBP aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q14011

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3-5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.01-0.03 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chinese hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Oncorhynchus mykiss": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
See full target information CIRBP
style
left-column

Publications (12)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 55: PubMed39791211

2025

Intracellular CIRP promotes liver regeneration via STAT3 signaling pathway activation after partial hepatectomy in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Wang,Mengzhou Wang,Wuming Liu,Lin Zhang,Jia Zhang,Junzhou Zhao,Zheng Wu,Yi Lyu,Rongqian Wu

Journal of cellular and molecular medicine 28:e70084 PubMed39400399

2024

AAV9-mediated CIRP gene transfer protects against cardiac dysfunction and remodelling in a rat model of myocardial infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Zhong,Shuang Yang,Can Fang,Yanjun Li,Siwei Song,Minxiao Chen,Jingru Chen

Journal of experimental & clinical cancer research : CR 40:275 PubMed34465343

2021

CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/β-catenin signaling via CTNNB1.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Liao,Jianguo Feng,Weichao Sun,Chao Wu,Jingyao Li,Tao Jing,Yuteng Liang,Yonghui Qian,Wenlan Liu,Haidong Wang

International journal of molecular sciences 22: PubMed34502391

2021

The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Matthias Kübler,Sebastian Beck,Lisa Lilian Peffenköver,Philipp Götz,Hellen Ishikawa-Ankerhold,Klaus T Preissner,Silvia Fischer,Manuel Lasch,Elisabeth Deindl

Brain and behavior 10:e01618 PubMed32285591

2020

Cold-inducible RNA-binding protein contributes to intracerebral hemorrhage-induced brain injury via TLR4 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Zhou,Shengtao Cui,Wei Duan,Jianrong Zhang,Jiacheng Huang,Li Wang,Zili Gong,Yu Zhou

Circulation research 126:1706-1720 PubMed32212953

2020

Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.

Applications

Unspecified application

Species

Unspecified reactive species

Duanyang Xie,Li Geng,Ke Xiong,Tingting Zhao,Shuo Wang,Jinfeng Xue,Cheng Wang,Guanghua Wang,Zhiqiang Feng,Huixing Zhou,Yini Li,Li Li,Yi Liu,Zhigang Xue,Jian Yang,Honghui Ma,Dandan Liang,Yi-Han Chen

The Journal of comparative neurology 527:2885-2895 PubMed31116410

2019

Nerve regeneration in rat peripheral nerve allografts: Evaluation of cold-inducible RNA-binding protein in nerve storage and regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Zijian Li,Song Zhang,Jinxiu Li,Huanhuan Zeng,Yi Wang,Yingru Huang

Molecular therapy. Nucleic acids 14:329-338 PubMed30665182

2019

Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Angela Downie Ruiz Velasco,Sabine M J Welten,Eveline A C Goossens,Paul H A Quax,Juri Rappsilber,Gracjan Michlewski,A Yaël Nossent

Andrology 7:244-250 PubMed30461215

2018

The regulation of CIRBP by transforming growth factor beta during heat shock-induced testicular injury.

Applications

Unspecified application

Species

Unspecified reactive species

M Rao,D Ke,G Cheng,S Hu,Y Wu,Y Wang,F Zhou,H Liu,C Zhu,W Xia

Life sciences 208:315-324 PubMed29857073

2018

Exogenous hydrogen sulfide ameliorates high glucose-induced myocardial injury & inflammation via the CIRP-MAPK signaling pathway in H9c2 cardiac cells.

Applications

WB

Species

Unspecified reactive species

Hong-Lei Zhao,Bao-Quan Wu,Ying Luo,Wen-Ying Zhang,Yun-Ling Hao,Jin-Jie Liang,Fang Fang,Wei Liu,Xie-Hui Chen
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB233711

Anti-CIRP antibody [6E12D5]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIRP antibody [6E12D5] (AB233711)

  • 0
  • 0
Primary Antibodies

AB191885

Anti-CIRP antibody [EPR18783]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CIRP antibody [EPR18783] (AB191885)

  • 4
  • 3
Primary Antibodies

AB238946

Anti-CIRP antibody [EPR18783] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CIRP antibody [EPR18783] - BSA and Azide free (AB238946)

  • 0
  • 0
Primary Antibodies

AB166775

Anti-CIRP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIRP antibody (AB166775)

  • 0
  • 0

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 74
Primary Antibodies

AB303565

Anti-CD68 antibody [RM1031]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-CD68 antibody [RM1031] (AB303565)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com