AB191447
Anti-CISH/CIS antibody - C-terminal
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(2 Publications )
Rabbit Polyclonal CISH/CIS antibody. C-terminal. Suitable for IHC-P, WB and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CISH aa 200 to C-terminus.
2 Images
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CISH/CIS antibody - C-terminal (AB191447)
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling CISH/CIS with ab191447 at 1 μg/ml.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CISH/CIS antibody - C-terminal (AB191447)
Immunohistochemical analysis of paraffin-embedded rat kidney tissue labeling CISH/CIS with ab191447 at 1 μg/ml.
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Primary Antibodies
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Reactivity data
{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
Properties and storage information
Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
Product protocols
For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Alternative Names
G18, CISH, Cytokine-inducible SH2-containing protein, CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCS
Publications (2)
Recent publications for all applications. Explore the full listand refine your search
Nature communications 14:4655 PubMed37537219
2023
Neoadjuvant Afatinib for stage III EGFR-mutant non-small cell lung cancer: a phase II study.
Applications
Unspecified application
Species
Unspecified reactive species
Dongliang Bian,Liangdong Sun,Junjie Hu,Liang Duan,Haoran Xia,Xinsheng Zhu,Fenghuan Sun,Lele Zhang,Huansha Yu,Yicheng Xiong,Zhida Huang,Deping Zhao,Nan Song,Jie Yang,Xiao Bao,Wei Wu,Jie Huang,Wenxin He,Yuming Zhu,Gening Jiang,Peng Zhang
PLoS biology 17:e2006571 PubMed30653498
2019
Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.
Applications
Unspecified application
Species
Unspecified reactive species
Wenxin Song,Qi Luo,Yuping Zhang,Linkang Zhou,Ye Liu,Zhilong Ma,Jianan Guo,Yuedong Huang,Lili Cheng,Ziyi Meng,Zicheng Li,Bin Zhang,Siqi Li,Sook Wah Yee,Hao Fan,Peng Li,Kathleen M Giacomini,Ligong Chen
Product promise
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