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AB307692

Anti-Claudin 1 antibody [EPR25359-48]

  • BOND RX™ Validated
  • 20ul selling size
  • RabMAb
  • Recombinant
  • KO Validated
  • What is this?

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(29 Publications)

Anti-Claudin 1 antibody [EPR25359-48] (ab307692) is a rabbit monoclonal antibody detecting Claudin 1 in Western Blot, IP, IHC-P, ICC/IF. Suitable for Human, Mouse, Rat.

- KO validated for confirmed specificity
- Biophysical QC for unrivalled batch-batch consistency

View Alternative Names

Claudin-1, Cldn1

10 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Immunohistochemical analysis of paraffin-embedded Human gastric adenocarcinoma labeling Claudin 1 with ab307692 at 1/100 followed by a LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Membranous staining on human gastric adenocarcinoma (PMID : 24535143). The section was incubated with ab307692 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins.

Immunocytochemistry/ Immunofluorescence - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • ICC/IF

Lab

Immunocytochemistry/ Immunofluorescence - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Immunofluorescent analysis of 4% Paraformaldehyde-fixed, 0.1% TritonX-100 permeabilized CLDN1 KO A431(CLDN1 knockout human epidermoid carcinoma epithelial cell) cells labelling Claudin 1 with ab307692 at 1/250 dilution, followed by AlexaFluor®488 Goat anti-Rabbit secondary (ab150077) antibody at 1/1000 dilution (Green).

Anti-alpha Tubulin antibody [DM1A] - Microtubule Marker (Alexa Fluor® 594) ( ab195889 ) was used to counterstain tubulin at 1/200 dilution (Magenta). The Nuclear counterstain was DAPI (Blue).

Secondary antibody only control : Secondary antibody is AlexaFluor488 Goat anti-Rabbit secondary (ab150077) at 1/1000 dilution.

Confocal image showing membranous and cytoplasmic staining in wildtype A431 cells and showing no staining in CLDN1 knockout A431 cells.
Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling Claudin 1 with ab307692 at 1/100 followed by a LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Membranous staining on human colon (PMID : 25038829). The section was incubated with ab307692 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Immunohistochemical analysis of paraffin-embedded (A) Parental A431 (h tissue labeling Claudin 1 with ab307692 at 1/500 (1.028 μg/ml) followed by a LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Positive staining on parental A431 (human epidermal carcinoma cells) cell pellet, negative staining on CLDN1 knockout A431 cell pellet (ab261889). The section was incubated with ab307692 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Immunohistochemical analysis of paraffin-embedded Mouse breast cancer tissue labeling Claudin 1 with ab307692 at 1/100 followed by a LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Membranous staining on mouse breast cancer. The section was incubated with ab307692 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Immunohistochemical analysis of paraffin-embedded Mouse colon tissue labeling Claudin 1 with ab307692 at 1/100 followed by a LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Membranous staining on mouse colon (PMID : 24626855). The section was incubated with ab307692 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Immunohistochemical analysis of paraffin-embedded Rat colon tissue labeling Claudin 1 with ab307692 at 1/100 followed by a LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Membranous staining on rat colon. The section was incubated with ab307692 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is LeicaDS9800 (Bond™ Polymer Refine Detection) at Ready to use dilution. Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins.

Immunoprecipitation - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • IP

Lab

Immunoprecipitation - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

Claudin 1 was immunoprecipitated from 0.35 mg ab307692 IP in Mouse liver tissue lysate with ab307692 at 30. Western blot was performed on the immunoprecipitate using ab307692 at 1000 dilution.

All lanes:

Immunoprecipitation - Anti-Claudin 1 antibody [EPR25359-48] (ab307692) at 1/1000 dilution

Lane 1:

Mouse liver tissue lysate at 10 µg

Lane 2:

ab307692 at 1/30 IP in Mouse liver tissue lysate at 10 µg

Lane 3:

Rabbit monoclonal IgG (<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a>) instead of ab307692 in mouse liver whole cell lysate at 10 µg

Secondary

All lanes:

Immunoprecipitation - VeriBlot for IP Detection Reagent (HRP) (<a href='/en-us/products/reagents/veriblot-for-ip-detection-reagent-hrp-ab131366'>ab131366</a>) at 1/5000 dilution

Observed band size: 19 kDa

false

Exposure time: 41s

Western blot - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • WB

Lab

Western blot - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

All lanes:

Western blot - Anti-Claudin 1 antibody [EPR25359-48] (ab307692) at 1/1000 dilution

Lane 1:

A431 whole cell lysate at 20 µg

Lane 2:

CLDN1 knockout A431 whole cell lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Observed band size: 19 kDa

false

Exposure time: 3s

Western blot - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)
  • WB

Lab

Western blot - Anti-Claudin 1 antibody [EPR25359-48] (AB307692)

In Western blot, Anti-GAPDH antibody [EPR16891] - Loading Control (ab181602) staining at 1/1000000 dilution.

ab307692 may serve as a viable alternative to ab180158 in Western blot.

Lanes 1 - 6:

Western blot - Anti-Claudin 1 antibody [EPR25359-48] (ab307692) at 1/1000 dilution

Lanes 7 - 12:

Western blot - Anti-Claudin 1 antibody [EPR9306] (<a href='/en-us/products/primary-antibodies/claudin-1-antibody-epr9306-ab180158'>ab180158</a>) at 1/1000 dilution

Lanes 1 and 7:

Mouse kidney at 10 µg

Lanes 2 and 8:

Mouse liver at 10 µg

Lanes 3 and 9:

Mouse colon at 10 µg

Lanes 4 and 10:

Rat kidney at 10 µg

Lanes 5 and 11:

Rat liver at 10 µg

Lanes 6 and 12:

Rat colon at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Observed band size: 19 kDa

false

Exposure time: 60s

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR25359-48

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

IP, ICC/IF, IHC-P, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

What is this antibody validated in?
Anti-Claudin 1 antibody [EPR25359-48] (ab307692) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.

What is the molecular weight of Claudin 1?
Anti-Claudin 1 [EPR25359-48] (ab307692) specifically detects a band for Claudin 1 (UniProt: O88551) at a molecular weight of 22kDa.

Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies.

Specificity confirmed
The specificity of Anti-Claudin 1 antibody [EPR25359-48] (ab307692) has been confirmed by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) testing in Cldn1 Knockout A431 cell line, ab261889.

Other related products
We have a range of other formats of antibody clone [EPR25359-48] also available for your convenience: ab307692, Carrier free - ab307693, Alexa Fluor® 488 - ab315954, Alexa Fluor® 647 - ab316340

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Claudin 1 also known as CLDN1 is a protein that plays a fundamental role in the formation of tight junctions in the epithelial cells. This claudin protein has a molecular weight of approximately 22 kDa. You can find it expressed in various tissues including the skin liver kidney and lungs. Claudin 1 belongs to the claudin family which consists of transmembrane proteins involved in sealing the space between adjacent cells therefore ensuring tissue integrity.
Biological function summary

This claudin protein contributes to establishing and maintaining the barrier function that controls paracellular transport which is the movement of substances between cells. Claudin 1 participates as a critical component of the tight junction complex and it interacts with other proteins such as occludin and zonula occludens. These interactions contribute to the regulation and maintenance of cell polarity and signaling.

Pathways

Claudin 1 is involved in the epithelial cell signaling pathways that influence cellular proliferation and differentiation. One significant pathway is the Wnt signaling pathway where claudin 1 cooperates with other claudins and proteins like Β-catenin to regulate gene transcription. Additionally it is implicated in the MAPK pathway which involves signaling cascades that affect cell growth division and response to external stress.

Claudin 1 shows a strong association with cancers particularly hepatocellular carcinoma and melanoma. In these conditions changes in claudin 1 expression levels can affect tumor progression and metastasis. It also associates with other proteins like E-cadherin impacting cell adhesion and epithelial-mesenchymal transition in cancerous cells. Moreover abnormalities in claudin 1 expression relate to skin disorders such as ichthyosis which is marked by a dysfunction in the skin barrier.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
See full target information Cldn1
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Publications (29)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in microbiology 16:1655522 PubMed41048511

2025

Sitagliptin ameliorates microbial dysbiosis and enhances gut barrier integrity in streptozotocin-induced type 2 diabetic rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Chang,Yuanjiang Zhou,Fanlin Zhou,Jie Liang,Yu Li,Mingyuan Tian

Cell death discovery 11:417 PubMed40883266

2025

METTL3-mediated m6A modification of circCDKAL1 regulates macrophage M1 polarization and nasal epithelial cell barrier function in allergic rhinitis through IGF2BP2/JARID2/HMGB1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiabin Zhan,Dan Luo,Yunlong Fu,Yu Zhou,Rui Li,Xin Wei

Integrative cancer therapies 24:15347354251368410 PubMed40847988

2025

Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaqi Cui,Wuhong Wang,Zhongjia Yi,Huan Tian,Hui Wang,Chunyun Jiang,Yiliu Chen,Dajin Pi,Qianjun Chen,Yingchao Wu

Histology and histopathology :18968 PubMed40740145

2025

Mechanism of the protective effect of 2,3,5,4'-Tetrahydroxy stilbene-2-O-β-D-glucoside on MPTP-induced Parkinson's disease mice.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Wu,Xiaolin Dong,Qingyun Li,Yanping Li,Furong Jin,Jingting Lu,Chengda Han,Lianbing Lin

Nature communications 16:6778 PubMed40701965

2025

Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity.

Applications

Unspecified application

Species

Unspecified reactive species

Sara D Lolansen,Eszter O Révész,Søren N Andreassen,Marleen Trapp,Chiara Salio,Marco Sassoé-Pognetto,Jens Velde Andersen,Emil W Westi,Trine L Toft-Bertelsen,Jonathan H Wardman,Anne-Kristine Meinild Lundby,Flemming Dela,Annarita Patrizi,Blanca I Aldana,Nanna MacAulay

Molecular medicine (Cambridge, Mass.) 31:258 PubMed40681992

2025

FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chenye Zhao,Xiaopeng Li,Mingchao Mu,Liyong Quan,Hang Yuan,Jianbao Zheng,Wei Zhao,Xuejun Sun,Junhui Yu

PloS one 20:e0327085 PubMed40591569

2025

Cl-amidine confers organ protection and improves survival in hemorrhagic shock rats via the PAD4-CitH3-NETs axis.

Applications

Unspecified application

Species

Unspecified reactive species

Huiting Yun,Yunfei Chi,Bin Wei,Hailiang Bai,Weihua Cao,Zheng Zhang,Yufang Zhang,Quanxi Zhang,Hongjie Duan

Journal of microbiology and biotechnology 35:e2412067 PubMed40582762

2025

Effects of Acute Abdomen III on Sepsis-Induced Intestinal Damage in a Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Wang,Jingjing Hu,Fangyu Hu,Yuexuan Chen,Ming Fang,Yuanling Ye

Virulence 16:2514789 PubMed40474676

2025

Fungal β-glucan instructed miR-32-5p modulates Dectin-1 signaling mediated inflammation, reactive oxygen species and apoptosis through polarization of "M2a-like" macrophage in colitis.

Applications

Unspecified application

Species

Unspecified reactive species

Liu Yang,Chengcheng Liu,Hanyu Zhu,Zixu Wang,Qinai Luo,Yuzhe Huang,Hao Wang,Min Hu,Jing Shao

Journal of inflammation research 18:6263-6280 PubMed40391232

2025

Si-Ni Decoction as a Potential Treatment for Ulcerative Colitis: Modulation of Gut Microbiota and AKT1 Inhibition Through Network Pharmacology and in vivo Validation.

Applications

Unspecified application

Species

Unspecified reactive species

Lihao Shi,Leilei Chen,Guiyuan Jin,Yonghong Yang,Fengqin Zhu,Guangxi Zhou
View all publications
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