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AB24792

Anti-Claudin 10 antibody

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(7 Publications)

Rabbit Polyclonal Claudin 10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 7 publications.

View Alternative Names

Claudin-10, Oligodendrocyte-specific protein-like, OSP-like, CLDN10

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p>Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as Claudin 10 also referred to as CLDN10 is a member of the claudin family essential for formation and maintenance of tight junctions. Claudin 10 has a molecular weight of approximately 24 kDa. This protein is expressed widely across various tissues with significant levels in the kidney liver and pancreas. Its main role involves controlling the permeability of epithelial barriers contributing to paracellular transport regulation.
Biological function summary

The function of Claudin 10 includes its involvement in forming and maintaining tight junction strands within epithelial and endothelial cells. It participates in a complex with other claudins to create selectively permeable barriers that regulate ion transport. Claudin 10 plays a role in determining cation selectivity and permeability impacting various physiological processes such as electrolyte balance and fluid homeostasis. In kidney tubules it especially influences the reabsorption and secretion of ions.

Pathways

Claudin 10 interacts with signaling mechanisms that regulate epithelial tight junction integrity. One significant pathway is the Wnt signaling pathway which influences cell polarity and growth affecting tight junction dynamics. Claudin 10 also associates with proteins related to the Par3/Par6/aPKC complex within these pathways. Its function intertwines with those of other tight junction proteins such as ZO-1 and occludin forming a network vital for epithelial cell barrier function and tissue homeostasis.

Altered expression of Claudin 10 has links to kidney disorders such as hypermagnesemia with hypocalciuria due to its important role in magnesium reabsorption. Additionally changes in Claudin 10 function associate with certain liver conditions where disrupted tight junctions may lead to compromised epithelial barrier function. This protein's interaction through disorders often involves connections with the chloride channel protein CLCNKB highlighting its role in ion balance and transport.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Forms paracellular channels : polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability.. Isoform 1. Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed : 19383724, PubMed : 28686597, PubMed : 28771254, PubMed : 35650657, PubMed : 36008380).. Isoform 2. Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis.
See full target information Claudin-10
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Endocrinology 164: PubMed36683433

2023

Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda H Winningham,Sally A Camper

Journal of cell communication and signaling 13:395-405 PubMed30796717

2019

CLDN10 promotes a malignant phenotype of osteosarcoma cells via JAK1/Stat1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Zhang,Xianbin Wang,Aiyu Wang,Qian Li,Ming Zhou,Tao Li

The Korean journal of thoracic and cardiovascular 47:262-8 PubMed25207224

2014

Prognostic significance of claudin 4 in completely resected adenocarcinoma of the lung.

Applications

IHC

Species

Unspecified reactive species

Min Cheol Chae,Chang Kwon Park,Dong Yoon Keum,Ilseon Hwang,Kun Young Kwon,Byeong Churl Jang

Methods in molecular biology (Clifton, N.J.) 762:371-82 PubMed21717371

2011

Enhanced immunohistochemical resolution of claudin proteins in glycolmethacrylate-embedded tissue biopsies.

Applications

Unspecified application

Species

Unspecified reactive species

Jane E Collins,Adam Kirk,Sara K Campbell,Juan Mason,Susan J Wilson

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 25:2107-19 PubMed20124215

2010

Differential expression of claudin tight junction proteins in the human cortical nephron.

Applications

IHC-Fr

Species

Human

Adam Kirk,Sara Campbell,Paul Bass,Juan Mason,Jane Collins

Biology of reproduction 78:342-51 PubMed17928628

2007

Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.

Applications

Unspecified application

Species

Unspecified reactive species

Evemie Dubé,Louis Hermo,Peter T K Chan,Daniel G Cyr

Journal of andrology 28:784-97 PubMed17522420

2007

Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility.

Applications

Unspecified application

Species

Unspecified reactive species

Louis Hermo,Nadine Korah,Mary Gregory,Lauren Ye Liu,Daniel G Cyr,Alessandra D'Azzo,Charles E Smith
View all publications
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