Anti-Claudin 17 antibody [EPR15483] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Claudin 17 also known as CLDN17 is a member of the claudin family of proteins essential for the formation of tight junctions in epithelial cells. Weighing approximately 24 kDa Claudin 17 plays a mechanical role in regulating paracellular transport which means it controls the flow of molecules between cells. Expression of this protein occurs mainly in the kidney and liver epithelia where it contributes to the barrier function of these tissues.

Biological function summary

Claudin 17 functions to maintain the selective permeability of epithelial barriers. It is part of the tight junction complex a group of proteins that includes other claudins occludin and junctional adhesion molecules. This complex ensures that tissues maintain homeostasis by controlling the diffusion of solutes and ions across epithelial layers. Claudin 17 also contributes to the polarity and differentiation of epithelial cells impacting how these cells interact with their environment.

Pathways

Researchers have identified Claudin 17 as an important player in the regulation of the paracellular transport pathway and its involvement in maintaining the epithelial barrier function. It participates in pathways that involve sodium and chloride ion transport closely interacting with proteins like Claudin 8 and Claudin 1. Such interactions balance ion transport and cellular permeability important for proper epithelial function.

Associated diseases and disorders

Researchers have explored Claudin 17's involvement in conditions such as electrolyte imbalance and kidney dysfunction. Its altered expression has been connected to Claudin 3 in renal disorders impacting tight junction integrity. Misregulation could lead to disruptions in ion balance contributing to disease progression. Understanding how Claudin 17 relates to these conditions can drive advancements in therapeutic strategies against epithelial barrier-related diseases.