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AB236726

Anti-Claudin 20 antibody

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(1 Publication)

Rabbit Polyclonal Claudin 20 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CLDN20 aa 1-100.

View Alternative Names

Claudin-20, CLDN20

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Claudin 20 antibody (AB236726)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Claudin 20 antibody (AB236726)

HepG2 (human liver hepatocellular carcinoma cell line) cells labeling Claudin 20 (green) using ab236726 at 1/100 dilution in ICC/IF, folowed by Alexa Fluor 488-congugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human CLDN20 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P56880

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Claudin 20 also known as CLDN20 is a protein that functions as a structural component in tight junctions. Claudins are a group of proteins important for the maintenance of cell polarity and barrier function in epithelial and endothelial cell layers. Claudin 20 has a low molecular weight of approximately 23 kDa. This protein is predominantly expressed in the kidney lung and intestines indicating its functional significance in these organs.
Biological function summary

Claudin 20 contributes to the paracellular transport by creating selective permeability barriers between epithelial cells. It associates with other claudin proteins to form tight junction strands within the cellular structure. These strands regulate the passage of ions and small molecules thereby maintaining the homeostasis of tissues. The protein often interacts with ZO-1 which is a tight junction-associated protein to stabilize its position within the junction.

Pathways

Claudin 20 plays an integral role in the epithelial barrier function pathway. It is central in maintaining the integrity and permeability of epithelial barriers working alongside proteins such as claudin 1 and claudin 4. It also contributes to the developmental and maintenance aspects of tight junctions participating in the signaling pathways that control cellular adhesion and communication. Alterations in these pathways can lead to varied physiological responses.

Claudin 20 has been implicated in certain kidney disorders such as nephrotic syndrome due to its role in maintaining the glomerular filtration barrier. It also relates to lung diseases like pulmonary fibrosis where tight junction integrity is compromised. Claudin 20 interacts with other claudin proteins such as claudin 16 in the development and progression of these conditions highlighting its significant role in disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
See full target information CLDN20
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 20:e1012766 PubMed39621795

2024

Flaviviruses induce ER-specific remodelling of protein synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Ho Him Wong,Dorian Richard Kenneth Crudgington,Lewis Siu,Sumana Sanyal
View all publications
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Product promise

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