AB187119

Anti-Claudin 6 + Claudin 9 antibody [YD9H8]

Name: Anti-Claudin 6 + Claudin 9 antibody [YD9H8] (ab187119) | Abcam
Brand: Abcam Limited
SKU: AB187119

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(1 Publication)

Rat Monoclonal Claudin 6 antibody. Carrier free. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human CLDN6.

View Alternative Names

UNQ757/PRO1488, CLDN6, Claudin-6, Skullin

1 Images

Flow Cytometry - Anti-Claudin 6 + Claudin 9 antibody [YD9H8] (AB187119)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Claudin 6 + Claudin 9 antibody [YD9H8] (AB187119)

Flow cytometry analysis of BOSC23 cells transiently transfected with expression vectors encoding either Claudin 9 (red curve), Claudin 6 (green curve) or a control transfectant; using ab187119 at 1.2 μg/10⁶ cells. PE-conjugated secondary antibodies were used for the analysis.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

YD9H8

Isotype

IgG2b

Carrier free

Yes

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Native Full Length Protein corresponding to Human CLDN6.

P56747

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1.2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p>ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.2 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Claudin 6 and Claudin 9 are integral membrane proteins that function as key components of tight junctions acting mechanically to regulate the paracellular barrier permeability in epithelial cells. These proteins which weigh approximately 23 kDa and 22 kDa respectively form networks that control the passage of ions and small molecules in tissue barriers. Claudin 6 (also known as CLDN6) is expressed in various tissues during embryonic development but shows limited presence in adult tissues. Claudin 9 (also recognized by its gene name CLDN9) displays expression in inner ear cells and other specific epithelial regions.

Biological function summary

These proteins help maintain tissue integrity by creating selective barriers that influence ion selectivity and cellular polarity. Claudin 6 and Claudin 9 are part of larger tight junction complexes that include other claudin family members and associated proteins like occludin and ZO-1. These complexes are essential for maintaining the proper function of epithelial and endothelial tissues ensuring that cells coordinate efficiently in forming structured tissue layers.

Pathways

The engagement of Claudin 6 and Claudin 9 in tight junction pathways impacts epithelial barrier processes and various signaling pathways. They play roles in the regulation of epithelial cell migration and proliferation through connections to proteins such as ZO-1 and influence signal transduction cascades like the Wnt/β-catenin pathway. These interactions highlight their significances in maintaining homeostasis and responding to physiological stimuli.

Alterations in Claudin 6 and Claudin 9 expression or function associate with conditions like cancer and hearing loss. Dysregulation of Claudin 6 has been linked to several cancers affecting tumor progression and metastasis often interacting with proteins such as E-cadherin. Claudin 9’s role in hearing connects to its function in maintaining the ion balance within the cochlea and malfunction can result in nonsyndromic hearing loss possibly in conjunction with other tight junction proteins like claudin 14.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Plays a major role in tight junction-specific obliteration of the intercellular space.. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

See full target information CLDN6

Additional targets

Claudin 9

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 17:2837-2844 PubMed29257268

2017

Activation of the LKB1‑SIK1 signaling pathway inhibits the TGF‑β‑mediated epithelial‑mesenchymal transition and apoptosis resistance of ovarian carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Hong,Jianmei Zhang,Wenlan Yang

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Claudin 6 + Claudin 9 antibody [YD9H8]

Flow Cytometry - Anti-Claudin 6 + Claudin 9 antibody [YD9H8] (AB187119)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Additional targets

Publications (1)

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