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AB192398

Anti-Claudin 9 antibody

5

(1 Review)

|

(4 Publications)

Rabbit Polyclonal Claudin 9 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human Claudin 9 aa 150 to C-terminus.

View Alternative Names

Claudin-9, CLDN9

1 Images
Western blot - Anti-Claudin 9 antibody (AB192398)
  • WB

Supplier Data

Western blot - Anti-Claudin 9 antibody (AB192398)

All lanes:

Western blot - Anti-Claudin 9 antibody (ab192398) at 1/500 dilution

Lane 1:

A549 (human lung carcinoma cell line) whole cell lysate

Lane 2:

RAW 264.7 (mouse macrophage cell line transformed with Abelson murine leukemia virus) whole cell lysate

Lane 3:

PC-12 (rat adrenal gland pheochromocytoma cell line) whole cell lysate

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Claudin 9 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O95484

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab192398 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Claudin-9 also known as CLDN9 is a member of the claudin protein family. This protein plays an important role in forming tight junctions which are responsible for regulating paracellular permeability in epithelial and endothelial cell sheets. Claudin-9 has a predicted mass of approximately 23 kDa. It is primarily expressed in the inner ear specifically in the cochlea and has vital functions in maintaining the permeability barrier and the structural integrity of cell layers.
Biological function summary

Claudin-9 engages in maintaining the tight junction barrier function of epithelial cells. It operates within a complex interacting closely with other claudin family members to establish the selective paracellular barrier important for ion balance and cellular homeostasis. These interactions allow claudin-9 to contribute significantly to the physiology of tissues where it is expressed impacting hearing function through ion permeability regulation in the cochlear epithelium.

Pathways

Claudin-9 is an integral component of pathways involved in cell-to-cell adhesion and cell polarity maintenance. It participates prominently in the tight junction pathway which is tightly regulated for maintaining the fundamental structure of epithelial layers. In this context it works alongside related proteins such as occludin and certain zonula occludens proteins which fortify the overall structure and signaling pathways essential for epithelial cell function.

Mutations or dysregulation of claudin-9 have been implicated in particular hearing impairments. Sensorineural hearing loss a condition attributed to malfunction in the inner ear's sensory parts aligns with malfunctions in claudin-9 activity. This condition can also have connections to other proteins involved in cochlear biology such as K+ channel proteins indicating how disruptions in tight junction function can affect ion homeostasis and lead to auditory dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
See full target information Claudin 9
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40332125

2025

Claudin-17 Deficiency Drives Vascular Permeability and Inflammation Causing Lung Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Mir S Adil,Varun Parvathagiri,Abdulaziz H Alanazi,Daulat Khulood,S Priya Narayanan,Payaningal R Somanath

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 30:722-731 PubMed31418417

2019

Claudin-9 enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyu Liu,Min Wang,Na Liang,Lianyue Guan

Molecular medicine reports 18:1271-1278 PubMed29901188

2018

Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa.

Applications

Unspecified application

Species

Unspecified reactive species

Luoluo Yang,Xun Sun,Xiangwei Meng

Diagnostic pathology 13:11 PubMed29402318

2018

Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Zhang,Haiming Wang,Qian Li,Yunpeng Liu,Peiqing Zhao,Tao Li
View all publications
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