Rat Monoclonal Claudin 9 antibody. Carrier free. Suitable for Flow Cyt, cELISA and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Claudin 9.
IgG2b
Rat
pH: 7.2
Constituents: 100% PBS
Liquid
Monoclonal
Flow Cyt | cELISA | |
---|---|---|
Human | Tested | Expected |
Mouse | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1.2 µg for 106 Cells | Notes ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info - | Notes - |
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Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Claudin-9, CLDN9
Rat Monoclonal Claudin 9 antibody. Carrier free. Suitable for Flow Cyt, cELISA and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Claudin 9.
IgG2b
Rat
pH: 7.2
Constituents: 100% PBS
Liquid
Monoclonal
Yes
YD4E9
Affinity purification Protein G
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
Claudin-9 also known as CLDN9 is a member of the claudin protein family. This protein plays an important role in forming tight junctions which are responsible for regulating paracellular permeability in epithelial and endothelial cell sheets. Claudin-9 has a predicted mass of approximately 23 kDa. It is primarily expressed in the inner ear specifically in the cochlea and has vital functions in maintaining the permeability barrier and the structural integrity of cell layers.
Claudin-9 engages in maintaining the tight junction barrier function of epithelial cells. It operates within a complex interacting closely with other claudin family members to establish the selective paracellular barrier important for ion balance and cellular homeostasis. These interactions allow claudin-9 to contribute significantly to the physiology of tissues where it is expressed impacting hearing function through ion permeability regulation in the cochlear epithelium.
Claudin-9 is an integral component of pathways involved in cell-to-cell adhesion and cell polarity maintenance. It participates prominently in the tight junction pathway which is tightly regulated for maintaining the fundamental structure of epithelial layers. In this context it works alongside related proteins such as occludin and certain zonula occludens proteins which fortify the overall structure and signaling pathways essential for epithelial cell function.
Mutations or dysregulation of claudin-9 have been implicated in particular hearing impairments. Sensorineural hearing loss a condition attributed to malfunction in the inner ear's sensory parts aligns with malfunctions in claudin-9 activity. This condition can also have connections to other proteins involved in cochlear biology such as K+ channel proteins indicating how disruptions in tight junction function can affect ion homeostasis and lead to auditory dysfunction.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
Terms & Conditions.
Flow cytometry analysis of BOSC23 cells transiently transfected with an expression vector encoding either Claudin 9 (red curve) or a control transfectant; using ab187116 at 1.2 μg/106 cells. PE-conjugated secondary antibodies were used for the analysis.
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