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AB187116

Anti-Claudin 9 antibody [YD4E9] - BSA and Azide free

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Anti-Claudin 9 antibody [YD4E9] - BSA and Azide free (ab187116) is a rat monoclonal antibody provided in a PBS only buffer for easy conjugation detecting Claudin 9 in Flow Cytometry, ELISA. Suitable for Human.

- BSA, sodium azide, and glycerol-free for easy conjugation

View Alternative Names

Claudin-9, CLDN9

1 Images
Flow Cytometry - Anti-Claudin 9 antibody [YD4E9] - BSA and Azide free (AB187116)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Claudin 9 antibody [YD4E9] - BSA and Azide free (AB187116)

Flow cytometry analysis of BOSC23 cells transiently transfected with an expression vector encoding either Claudin 9 (red curve) or a control transfectant; using ab187116 at 1.2 μg/106 cells. PE-conjugated secondary antibodies were used for the analysis.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

YD4E9

Isotype

IgG2b

Carrier free

Yes

Reacts with

Human

Applications

cELISA, Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Claudin 9.

O95484

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Reactivity data

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Product details

What is this antibody validated in?
Anti-Claudin 9 antibody [YD4E9] - BSA and Azide free (ab187116) is a rat monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), ELISA in Human samples.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2 Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Claudin-9 also known as CLDN9 is a member of the claudin protein family. This protein plays an important role in forming tight junctions which are responsible for regulating paracellular permeability in epithelial and endothelial cell sheets. Claudin-9 has a predicted mass of approximately 23 kDa. It is primarily expressed in the inner ear specifically in the cochlea and has vital functions in maintaining the permeability barrier and the structural integrity of cell layers.
Biological function summary

Claudin-9 engages in maintaining the tight junction barrier function of epithelial cells. It operates within a complex interacting closely with other claudin family members to establish the selective paracellular barrier important for ion balance and cellular homeostasis. These interactions allow claudin-9 to contribute significantly to the physiology of tissues where it is expressed impacting hearing function through ion permeability regulation in the cochlear epithelium.

Pathways

Claudin-9 is an integral component of pathways involved in cell-to-cell adhesion and cell polarity maintenance. It participates prominently in the tight junction pathway which is tightly regulated for maintaining the fundamental structure of epithelial layers. In this context it works alongside related proteins such as occludin and certain zonula occludens proteins which fortify the overall structure and signaling pathways essential for epithelial cell function.

Mutations or dysregulation of claudin-9 have been implicated in particular hearing impairments. Sensorineural hearing loss a condition attributed to malfunction in the inner ear's sensory parts aligns with malfunctions in claudin-9 activity. This condition can also have connections to other proteins involved in cochlear biology such as K+ channel proteins indicating how disruptions in tight junction function can affect ion homeostasis and lead to auditory dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
See full target information Claudin 9
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

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