Anti-ClC-K1 antibody

Target data

Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (PubMed : 11734858, PubMed : 12111250). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed : 11734858, PubMed : 12111250, PubMed : 18310267, PubMed : 18776122, PubMed : 19646679, PubMed : 20538786). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKA : BSND channels display mostly a linear current-voltage relationship with fast gating at negative potentials (PubMed : 11734858, PubMed : 12111250, PubMed : 18310267, PubMed : 18776122, PubMed : 20538786). Mediates transepithelial chloride transport from the lumen to interstitial compartment along the thin ascending limb of Henle's loop, contributing to generation of hypertonic medullary interstitium as a countercurrent system to achieve urine concentration (By similarity) (PubMed : 15044642). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed : 15044642, PubMed : 18310267, PubMed : 19646679).