Anti-Cleaved NEAS (Asp1185) antibody [EPR3830-17]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cleaved NEAS (Asp1185) also known as cleaved Notch extracellular truncation and NEAS is a significant enzymatic cleavage product of the Notch receptor involved in signal transduction. It has a mass of about 300 kDa. Cleavage occurs when the receptor undergoes proteolytic processing producing a functional subunit. This subunit is present in various tissues particularly active in developmental tissues and the nervous system. This localization suggests an important role in those areas for proper cell signaling and differentiation processes.

Biological function summary

The Notch intracellular domain (NICD) which arises after further cleavage is a part of the core Notch signaling pathway. Cleaved NEAS is part of a complex involving other cleavage events; it acts as an intermediary in the Notch signaling cascade. This role makes it important for cellular communication and regulation determining cell fate decisions and controlling differentiation and proliferation. Studies often identify its presence and function within the nuclear and membrane-associated areas indicating roles both in direct gene expression and membrane signaling domains.

Pathways

Cleaved NEAS interacts heavily with Delta/Serrate/LAG-2 (DSL) Notch ligands and influences the Notch signaling pathway. The processed NICD translocates to the nucleus affecting the transcription of target genes involved in developmental processes and immune system regulation. In addition to cooperating with ligands such as Jagged and Delta-like proteins NEAS has interactions that play a part in modulating important pathways like Wnt signaling revealing its role in coordinating diverse signaling networks.

Associated diseases and disorders

Cleaved NEAS’s dysregulation links it to various cancer types including leukemia and breast cancer. Overactive Notch signaling often due to abnormal cleaved NEAS activity can drive oncogenesis and influence tumor progression. NEAS interacts with regulatory proteins like P53 which is also implicated in tumor suppression making it a point of interest in therapeutic strategies. Additionally its association with neurodegenerative diseases such as Alzheimer's disease indicates its relevance in both proliferative and degenerative conditions further highlighting its biological importance.