AB239078

Anti-CLEC4C antibody [EPR21985]

20ul selling size
RabMAb
Recombinant
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(4 Publications)

Rabbit Recombinant Monoclonal CLEC4C antibody. Suitable for Flow Cyt, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 4 publications.

View Alternative Names

CD303, BDCA2, CLECSF11, CLECSF7, DLEC, HECL, UNQ9361/PRO34150, CLEC4C, C-type lectin domain family 4 member C, Blood dendritic cell antigen 2, C-type lectin superfamily member 7, Dendritic lectin, BDCA-2

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Immunohistochemical analysis of paraffin-embedded human cardiac muscle tissue labeling CLEC4C with ab239078 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

Negative control : Negative staining in human cardiac muscle (PMID : 11748283).

Counter stained with hematoxylin.

Flow Cytometry - Anti-CLEC4C antibody [EPR21985] (AB239078)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CLEC4C antibody [EPR21985] (AB239078)

Flow cytometric analysis of primary human peripheral blood mononuclear cell (PBMC) labeling CLEC4C with ab239078 at 1/60 dilution (right panel) compared with a Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730) (left panel). Goat Anti-Rabbit IgG Fc (Dylight^® 488) (ab98462) at 1/2000 dilution was used as the secondary antibody.

Gated on viable cells.

Note : CLEC4C and CD303 are alternative names for the same target.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Immunohistochemical analysis of paraffin-embedded human tonsil tissue labeling CLEC4C with ab239078 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Membranous staining in plasmacytoid dendritic cells (PDCs) of human tonsil (PMID : 23847189, PMID : 11748283). Counter stained with hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue labeling CLEC4C with ab239078 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Membranous staining in plasmacytoid dendritic cells (PDCs) of mouse spleen (PMID : 23847189, PMID : 11748283). Counter stained with hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Immunohistochemical analysis of paraffin-embedded rat spleen tissue labeling CLEC4C with ab239078 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Membranous staining in plasmacytoid dendritic cells (PDCs) of rat spleen (PMID : 23847189, PMID : 11748283). Counter stained with hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

Carrier free

Anti-CLEC4C antibody [EPR21985] - BSA and Azide free
660 APC

APC Anti-CLEC4C antibody [EPR21985]
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-CLEC4C antibody [EPR21985]
565 Alexa Fluor® 555

Alexa Fluor® 555 Anti-CLEC4C antibody [EPR21985]
603 Alexa Fluor® 568

Alexa Fluor® 568 Anti-CLEC4C antibody [EPR21985]
665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-CLEC4C antibody [EPR21985]
775 Alexa Fluor® 750

Alexa Fluor® 750 Anti-CLEC4C antibody [EPR21985]
HRP

HRP Anti-CLEC4C antibody [EPR21985]
578 PE

PE Anti-CLEC4C antibody [EPR21985]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR21985

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P, Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/60", "FlowCyt-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed : 11748283, PubMed : 21880719, PubMed : 25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed : 21880719, PubMed : 25995448). Binds to serum IgG (PubMed : 25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed : 11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed : 11748283, PubMed : 21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed : 11748283).

See full target information CLEC4C

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The Journal of experimental medicine 222: PubMed40227192

2025

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains.

Applications

Unspecified application

Species

Unspecified reactive species

Fanny Saidoune,Danyel Lee,Jeremy Di Domizio,Corentin Le Floc'h,Raphael Jenelten,Jérémie Le Pen,Vincent Bondet,Ana Joncic,Marie-Anne Morren,Vivien Béziat,Shen-Ying Zhang,Emmanuelle Jouanguy,Darragh Duffy,Charles M Rice,Curdin Conrad,Jacques Fellay,Jean-Laurent Casanova,Michel Gilliet,Ahmad Yatim

Nature communications 15:8690 PubMed39375367

2024

Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis.

Applications

Unspecified application

Species

Unspecified reactive species

Ciliang Jin,Penglei Jiang,Zhaoru Zhang,Yingli Han,Xue Wen,Lin Zheng,Wei Kuang,Jiangshan Lian,Guodong Yu,Xinyue Qian,Yue Ren,Miaomiao Lu,Lingling Xu,Weixin Chen,Jiyang Chen,Yuwei Zhou,Jinxia Xin,Ben Wang,Xi Jin,Pengxu Qian,Yida Yang

MedComm 5:e561 PubMed38721005

2024

PA28γ induces dendritic cell maturation and activates T-cell immune responses in oral lichen planus.

Applications

Unspecified application

Species

Unspecified reactive species

Yimei Wang,Qiyue Zhang,Xiaoting Deng,Ying Wang,Xin Tian,Shiyu Zhang,Yingqiang Shen,Xikun Zhou,Xin Zeng,Qianming Chen,Lu Jiang,Jing Li

Genome medicine 15:14 PubMed36869384

2023

Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Junjie Hu,Lele Zhang,Haoran Xia,Yilv Yan,Xinsheng Zhu,Fenghuan Sun,Liangdong Sun,Shuangyi Li,Dianke Li,Jin Wang,Ya Han,Jing Zhang,Dongliang Bian,Huansha Yu,Yan Chen,Pengyu Fan,Qiang Ma,Gening Jiang,Chenfei Wang,Peng Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CLEC4C antibody [EPR21985]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Flow Cytometry - Anti-CLEC4C antibody [EPR21985] (AB239078)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4C antibody [EPR21985] (AB239078)

Related conjugates and formulations (9)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (4)

Product promise