AB64881

Anti-CMKLR1 antibody

Name: Anti-CMKLR1 antibody (ab64881) | Abcam
Brand: Abcam Limited
SKU: AB64881
Price: 565 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(18 Publications)

Rabbit Polyclonal CMKLR1 antibody. Suitable for WB and reacts with Human samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human CMKLR1.

View Alternative Names

CHEMR23, DEZ, CMKLR1, Chemerin-like receptor 1, Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ

1 Images

Unknown

Western blot - Anti-CMKLR1 antibody (AB64881)

All lanes:

Western blot - Anti-CMKLR1 antibody (ab64881) at 1/500 dilution

Lane 1:

extracts from HepG2 cells (5-30µg total protein)

Lane 2:

extracts from HeLa cells (5-30µg total protein)

Lane 3:

extracts from 293 cells (5-30µg total protein)

Lane 4:

extracts from 293 cells (5-30µg total protein) and 5-10µg of the immunising peptide

Predicted band size: 42 kDa

Observed band size: 26 kDa,34 kDa,43 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human CMKLR1. The exact immunogen used to generate this antibody is proprietary information.

Q99788

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed : 27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism.. (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

See full target information CMKLR1

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Publications (18)

Recent publications for all applications. Explore the full list and refine your search

Diabetes, obesity & metabolism 27:1296-1313 PubMed39803714

2025

Chemerin loss-of-function attenuates glucagon-like peptide-1 secretion in exercised obese mice.

Applications

Unspecified application

Species

Unspecified reactive species

Qilong Zhang,Yi Jia,Yifan Guo,Xiaohan Yu,Ru Wang,Xiaohui Wang

Frontiers in immunology 15:1458684 PubMed39380984

2024

Activation of pro-resolving pathways mediate the therapeutic effects of thymosin beta-4 during -induced keratitis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxin Wang,Loveleen Banga,Abdul Shukkur Ebrahim,Thomas W Carion,Gabriel Sosne,Elizabeth A Berger

International journal of endocrinology 2024:7957018 PubMed39104601

2024

Chemerin Enhances Migration and Invasion of OC Cells via CMKLR1/RhoA/ROCK-Mediated EMT.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojing Sun,Yi Guo

Cancers 14: PubMed36077645

2022

Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response.

Applications

Unspecified application

Species

Unspecified reactive species

Meike Schmitt,Johanna Gallistl,Susanne Schüler-Toprak,Jürgen Fritsch,Christa Buechler,Olaf Ortmann,Oliver Treeck

Iranian journal of basic medical sciences 24:1107-1116 PubMed34804428

2021

Alpha-lipoic acid could attenuate the effect of chemerin-induced diabetic nephropathy progression.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Zhang,Jiawei Mu,Jinqiu Du,Ying Feng,Wenhui Xu,Mengmeng Bai,Huijuan Zhang

Journal of immunology (Baltimore, Md. : 1950) 206:2888-2899 PubMed34031150

2021

Selective Activation of MST1/2 Kinases by Retinoid Agonist Adapalene Abrogates AURKA-Regulated Septic Arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Preeti Yadav,Bharat Bhatt,Kithiganahalli Narayanaswamy Balaji

Frontiers in endocrinology 12:636784 PubMed33776932

2021

Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wisanee Wisanwattana,Kanjana Wongkrajang,Dong-Yi Cao,Xiao-Ke Shi,Zhong-Hui Zhang,Zong-Yuan Zhou,Fu Li,Qing-Gang Mei,Chun Wang,Apichart Suksamrarn,Guo-Lin Zhang,Fei Wang

International journal of molecular sciences 21: PubMed32580404

2020

Flutamide Alters the Expression of Chemerin, Apelin, and Vaspin and Their Respective Receptors in the Testes of Adult Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Malgorzata Brzoskwinia,Laura Pardyak,Agnieszka Rak,Alicja Kaminska,Anna Hejmej,Sylwia Marek,Malgorzata Kotula-Balak,Barbara Bilinska

Molecular reproduction and development 87:739-762 PubMed32557981

2020

Expression of chemerin and its receptors in the ovaries of prepubertal and mature gilts.

Applications

Unspecified application

Species

Unspecified reactive species

Edyta Rytelewska,Katarzyna Kisielewska,Marta Kiezun,Kamil Dobrzyn,Marlena Gudelska,Agnieszka Rak,Joelle Dupont,Barbara Kaminska,Tadeusz Kaminski,Nina Smolinska

International journal of molecular medicine 46:751-761 PubMed32468037

2020

Simvastatin inhibits the adipogenesis of bone marrow‑derived mesenchymal stem cells through the downregulation of chemerin/CMKLR1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Guo,Jianzhong Huo,Dou Wu,Haihu Hao,Xinghua Ji,Enzhe Zhao,Boyuan Nie,Qiang Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CMKLR1 antibody

Western blot - Anti-CMKLR1 antibody (AB64881)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Target data

Publications (18)

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