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AB198284

Anti-CMTM6 antibody - C-terminal

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(3 Publications)

Rabbit Polyclonal CMTM6 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CMTM6 aa 100 to C-terminus.

View Alternative Names

CKLFSF6, CMTM6, CKLF-like MARVEL transmembrane domain-containing protein 6, Chemokine-like factor superfamily member 6

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMTM6 antibody - C-terminal (AB198284)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMTM6 antibody - C-terminal (AB198284)

Immunohistochemical analysis of paraffin embedded human cervical cancer tissue labeling CMTM6 with ab198284 at 1/17 dilution.

Western blot - Anti-CMTM6 antibody - C-terminal (AB198284)
  • WB

Supplier Data

Western blot - Anti-CMTM6 antibody - C-terminal (AB198284)

10% SDS-PAGE

All lanes:

Western blot - Anti-CMTM6 antibody - C-terminal (ab198284) at 1/350 dilution

Lane 1:

Human placenta tissue lysate at 40 µg

Lane 2:

Human testis tissue lysate at 40 µg

Lane 3:

HeLa (Human epithelial cell line from cervix adenocarcinoma) cell lysate at 40 µg

Lane 4:

Raji (Human Burkitt's lymphoma cell line) cell lysate at 40 µg

Predicted band size: 20 kDa

false

Exposure time: 2min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human CMTM6 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NX76

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
See full target information CMTM6
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer science 112:4064-4074 PubMed34251713

2021

Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhao Ma,Han Wang,Fanbiao Meng,Yamei Han,Yefei Chen,Mingming Xiao,Hongjing Jiang,Zhentao Yu,Bo Xu

DNA and cell biology : PubMed33090010

2020

Expression and Clinical Significance of CMTM6 in Nonsmall Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xueyan Hou,Sisi He,Daquan Zhang,Chengli Yang,Yongli Shi,Kuanlin Zhang

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 14:2084-2096 PubMed31605795

2019

Quantitative Assessment of CMTM6 in the Tumor Microenvironment and Association with Response to PD-1 Pathway Blockade in Advanced-Stage Non-Small Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jon Zugazagoitia,Yuting Liu,Maria Toki,John McGuire,Fahad Shabbir Ahmed,Brian S Henick,Richa Gupta,Scott N Gettinger,Roy S Herbst,Kurt A Schalper,David L Rimm
View all publications
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