JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB204392

Anti-Codanin-1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Codanin-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus.

View Alternative Names

UNQ664/PRO1295, CDAN1, Codanin-1

5 Images
Immunocytochemistry/ Immunofluorescence - Anti-Codanin-1 antibody (AB204392)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Codanin-1 antibody (AB204392)

Immunofluorescent analysis of HeLa cells (PFA-fixed/Triton X-100 permeabilized) labeling Codanin-1 with ab204392 at 4 μg/ml (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IWY9

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Codanin-1 also known as Codanto is a protein encoded by the CDAN1 gene. It has a molecular mass of approximately 144 kDa. Codanin-1 is generally expressed in the nucleus of cells and is especially present in tissues with high rates of cellular proliferation like bone marrow and fetal liver. This protein plays a role in chromatin assembly and cell cycle regulation.
Biological function summary

Codanin-1 interacts with several cellular processes including DNA replication and repair. It forms part of a larger chromatin remodeling complex. This association highlights its influence on maintaining proper chromatin structure and function which is necessary for accurate gene expression and genomic stability. Codanin-1's involvement in the chromatin assembly process is essential for normal cell function.

Pathways

Codanin-1 interacts with processes related to chromatin remodeling and the DNA damage response. It is part of the chromatin assembly factor pathway which facilitates the integration and organization of new histones into chromatin. Codanin-1 is also potentially linked to the nucleosome assembly pathway. It interacts with proteins like ASF1A and ASF1B which are essential for histone chaperoning and nucleosome assembly during DNA replication.

Codanin-1 has a strong association with congenital dyserythropoietic anemia type I (CDA I) a rare form of anemia. This condition arises from mutations in the CDAN1 gene causing ineffective erythropoiesis. The Codanin-1 protein links with the hemoglobin subunit proteins during erythroid cell development and plays a critical role in red blood cell maturation. This connection highlights the importance of Codanin-1 in maintaining normal blood cell production and function.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

May act as a negative regulator of ASF1 in chromatin assembly.
See full target information CDAN1

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 10: PubMed34279220

2021

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.

Applications

Unspecified application

Species

Unspecified reactive species

Shintaro Ide,Yoshihiko Kobayashi,Kana Ide,Sarah A Strausser,Koki Abe,Savannah Herbek,Lori L O'Brien,Steven D Crowley,Laura Barisoni,Aleksandra Tata,Purushothama Rao Tata,Tomokazu Souma
View all publications

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com