Rabbit Polyclonal Codanin-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IWY9
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Target data
Function
May act as a negative regulator of ASF1 in chromatin assembly.
Alternative names
UNQ664/PRO1295, CDAN1, Codanin-1
Recommended products
Rabbit Polyclonal Codanin-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IWY9
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Codanin-1 also known as Codanto is a protein encoded by the CDAN1 gene. It has a molecular mass of approximately 144 kDa. Codanin-1 is generally expressed in the nucleus of cells and is especially present in tissues with high rates of cellular proliferation like bone marrow and fetal liver. This protein plays a role in chromatin assembly and cell cycle regulation.
- Biological function summary
Codanin-1 interacts with several cellular processes including DNA replication and repair. It forms part of a larger chromatin remodeling complex. This association highlights its influence on maintaining proper chromatin structure and function which is necessary for accurate gene expression and genomic stability. Codanin-1's involvement in the chromatin assembly process is essential for normal cell function.
- Pathways
Codanin-1 interacts with processes related to chromatin remodeling and the DNA damage response. It is part of the chromatin assembly factor pathway which facilitates the integration and organization of new histones into chromatin. Codanin-1 is also potentially linked to the nucleosome assembly pathway. It interacts with proteins like ASF1A and ASF1B which are essential for histone chaperoning and nucleosome assembly during DNA replication.
- Associated diseases and disorders
Codanin-1 has a strong association with congenital dyserythropoietic anemia type I (CDA I) a rare form of anemia. This condition arises from mutations in the CDAN1 gene causing ineffective erythropoiesis. The Codanin-1 protein links with the hemoglobin subunit proteins during erythroid cell development and plays a critical role in red blood cell maturation. This connection highlights the importance of Codanin-1 in maintaining normal blood cell production and function.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
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5 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (ab204392)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunocytochemistry/ Immunofluorescence - Anti-Codanin-1 antibody (ab204392)
Immunofluorescent analysis of HeLa cells (PFA-fixed/Triton X-100 permeabilized) labeling Codanin-1 with ab204392 at 4 μg/ml (green).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (ab204392)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (ab204392)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (ab204392)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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