Anti-Cofilin 1 + 2 antibody - Loading Control

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cofilin 1 and Cofilin 2 are actin-binding proteins known also as non-muscle cofilin and muscle cofilin respectively. Together they weigh approximately 19 kDa each. Both are essential in actin filament dynamics catalyzing the disassembly and severing of actin filaments. Cofilin 1 is ubiquitously expressed in various tissues whereas Cofilin 2 is mainly found in muscle tissues and hearts. Their expression patterns and functional properties make them critical in cellular processes involving cytoskeletal reorganization.

Biological function summary

These proteins interact with actin to modulate cytoskeletal structure and dynamics. They function by depolymerizing actin filaments an activity that is important in cellular processes like cell migration division and maintenance of cell shape. Cofilin often works as part of a complex with other proteins such as ADF (actin depolymerizing factor) enhancing its ability to modulate actin dynamics. These interactions are integral to cellular scaffolding ensuring proper cell function and adaptation to environmental cues.

Pathways

These proteins are pivotal in actin dynamics pathways and cellular signaling pathways like the Rho and Rac signaling pathways. The pathways dictate how cells change shape and move in response to signals. ADF and profilin are two significant proteins interacting with cofilin within these pathways. Cofilin essentially modulates actin filament turnover impacting diverse cellular processes and responses. Precise regulation of these pathways is vital for normal cellular behavior.

Associated diseases and disorders

Cofilin proteins are linked with various conditions including neurodegeneration and cardiomyopathy. Their dysregulation often leads to abnormal actin dynamics contributing to these disorders. For instance in Alzheimer's disease cofilin interacts with proteins like Tau contributing to neurofibrillary tangles. Additionally in cardiomyopathy cofilin dysfunction can negatively affect heart muscle function impacting proteins involved in muscle contraction. Understanding these links provides insights into potential therapeutic targets.