Anti-COLEC11 antibody

Target data

Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed : 21258343, PubMed : 23954398, PubMed : 25912189). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed : 25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed : 25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed : 17179669, PubMed : 25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed : 20956340, PubMed : 25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed : 21258343, PubMed : 28301481).