AB188533

Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal

Name: Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (ab188533) | Abcam
Brand: Abcam Limited
SKU: AB188533

Be the first to review this product! Submit a review

(3 Publications )

Rabbit Polyclonal Collagen alpha-1(XXVIII) chain antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human COL28A1 aa 1000 to C-terminus.

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (AB188533)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (AB188533)

Immunohistochemical analysis of paraffin embedded Human skin cancer tissue labeling Collagen alpha-1(XXVIII) chain with ab188533 antibody at a dilution of 1/1000.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (AB188533)

Immunohistochemical analysis of paraffin embedded Human kidney tissue labeling Collagen alpha-1(XXVIII) chain with ab188533 antibody at a dilution of 1/1000.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (AB188533)

Immunohistochemical analysis of paraffin embedded Human pancreas tissue labeling Collagen alpha-1(XXVIII) chain with ab188533 antibody at a dilution of 1/1000.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human COL28A1 aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q2UY09

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Collagen alpha-1(XXVIII) chain also known as COL28A1 is a protein involved in various structural and mechanical roles. This protein has a mass of approximately 119 kDa and is part of the extracellular matrix. We can find COL28A1 in skin cartilage and other connective tissues. Its unique structure contributes to biomechanical properties of tissues influencing rigidity and flexibility.

Biological function summary

Collagen alpha-1(XXVIII) chain plays a significant role in maintaining the structural integrity of tissues particularly within the extracellular matrix. It associates with other molecules to form a complex network that supports cell adhesion and tissue repair. This complex formation connects to collagenous domains and non-collagenous regions contributing to its functionality. COL28A1 is critical in maintaining tissue organization and facilitating cell signaling interactions.

Pathways

This protein is part of key pathways that involve tissue repair and extracellular matrix regulation. The TGF-beta signaling pathway is one of these where COL28A1 interacts with other collagens and matrix metalloproteinases (MMPs) to modulate matrix composition. Additionally the Wnt signaling pathway engages with COL28A1 influencing cell differentiation and migration. COL28A1 interacts with proteins like COL1A1 and MMPs to manage these processes effectively.

Collagen alpha-1(XXVIII) chain has associations with skin disorders and connective tissue diseases. Ehlers-Danlos syndrome a condition affecting connective tissue's elasticity shows connections to aberrant expression of COL28A1. Osteoarthritis another disorder linked to changes in cartilage and joint tissues may involve dysregulation of COL28A1 along with other collagens such as COL1A1. Understanding these links helps in deciphering the molecular basis of these disorders offering pathways for potential therapeutic interventions.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May act as a cell-binding protein.

See full target information COL28A1

Alternative Names

COL28, COL28A1, Collagen alpha-1(XXVIII) chain

style

left-column

Publications (3)

Recent publications for all applications. Explore the full listand refine your search

The Tohoku journal of experimental medicine : PubMed41062300

2025

Identification of KLHL35, WDR72, and WDR78 as Prognostic Biomarkers in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayou Ye,Tingting Zhang,Guangsheng Wang,Guofeng Bian,Aijun Chen,Xin Zhou

Renal failure 45:2187236 PubMed36883360

2023

COL28 promotes proliferation, migration, and EMT of renal tubular epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Linlin Li,Hong Ye,Qiaoling Chen,Lixin Wei

Journal of the renin-angiotensin-aldosterone system : JRAAS 2022:9582559 PubMed36518326

2022

Type XXVIII Collagen Regulates Renal Interstitial Fibrosis and Epithelial-Mesenchymal Transition by SREBP1-Mediated HKDC1 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Linlin Li,Qi Zou,Binbin Li,Lushi Huang,Lixin Wei

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (AB188533)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (AB188533)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen alpha-1(XXVIII) chain antibody - C-terminal (AB188533)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Reagents, Controls & Accessories

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Alternative Names

Publications (3)

Product promise