Anti-Collagen VI alpha 2 antibody [EPR7889(N)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Collagen VI alpha 2 also known as COL6A2 or anti-collagen VI is a protein that is an essential component of the extracellular matrix. It forms a part of the collagen VI complex which is important for connective tissue stability and function. COL6A2 has a molecular mass of approximately 130 kDa. It is widely expressed in various tissues including muscle skin and the basement membrane of blood vessels indicating its diverse functional role.

Biological function summary

The COL6A2 protein contributes to maintaining tissue integrity and resilience. It forms a beaded filament structure as part of a collagen VI tetramer when combined with other alpha chains (alpha 1 and alpha 3). These interactions at the molecular level help to provide tensile strength and structural support to many tissues especially in muscle where it impacts elasticity and repair mechanisms.

Pathways

COL6A2 and its associated complex participate in the extracellular matrix organization and cell adhesion pathways. In these processes it interacts with proteins such as integrins and laminins which are important for cellular attachment and communication. Such pathways underline the significant roles COL6A2 plays in maintaining normal tissue architecture and cellular environments.

Associated diseases and disorders

The COL6A2 protein has strong associations with conditions like myosclerosis and Bethlem myopathy. Mutations or dysfunctions in the COL6A2 gene can disrupt the extracellular matrix leading to musculoskeletal disorders. It also shows interactions with other proteins like dystrophin in these pathological states emphasizing its involvement in muscular integrity and function.