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AB172606

Anti-Collagen VI antibody [EPR7888(N)]

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(2 Publications)

Rabbit Recombinant Monoclonal COL6A1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

Collagen alpha-1(VI) chain, COL6A1

1 Images
Western blot - Anti-Collagen VI antibody [EPR7888(N)] (AB172606)
  • WB

Supplier Data

Western blot - Anti-Collagen VI antibody [EPR7888(N)] (AB172606)

All lanes:

Western blot - Anti-Collagen VI antibody [EPR7888(N)] (ab172606) at 1/1000 dilution

Lane 1:

Human skin lysate at 10 µg

Lane 2:

Human placenta lysate at 10 µg

Lane 3:

Human fetal heart lysate at 10 µg

Predicted band size: 109 kDa

false

  • Carrier free

    Anti-Collagen VI antibody [EPR7888(N)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7888(N)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Collagen VI also known as Collagen 6 is a type of collagen that plays an important role in the extracellular matrix. It consists of three different chains: α1(VI) α2(VI) and α3(VI) with a combined mass of approximately 140 kDa. This collagen type strongly associates with several tissues notably in skeletal muscle skin and the walls of blood vessels. Scientists often study collagen VI with specific collagen antibodies to understand its unique structural properties and its end which binds to other matrix components.
Biological function summary

Collagen VI contributes to structural integrity and cellular scaffolding within tissues. This protein is integral to the formation of microfibrillar networks part of a larger complex that connects the extracellular matrix to cells and other matrix components. Its protective role helps cells resist mechanical stress and the network provided by collagen VI powder stabilizes the tissue architecture. Additionally low endotoxin collagen is often preferable in research to minimize inflammatory responses during experimentation providing more accurate results.

Pathways

Collagen VI participates in extracellular matrix organization and mechanotransduction pathways. It functions alongside other proteins like collagen I and IV. In particular collagen VI interacts with cell surface receptors which influences cellular communication and signaling pathways. This interaction plays a role in transmitting mechanical signals that affect cellular behavior and function proving important for tissue maintenance and repair processes.

Mutations or malfunctions involving collagen VI can lead to significant clinical outcomes. It is prominently linked with disorders such as Ullrich congenital muscular dystrophy and Bethlem myopathy both affecting muscle and connective tissue. These conditions often involve disruptions in the assembly or function of the collagen VI network. Additionally related proteins like collagen I and integrin proteins can influence the progression and severity of these disorders illustrating the interconnected nature of these extracellular elements.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Collagen VI acts as a cell-binding protein.
See full target information COL6A1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular bioengineering 10:501-513 PubMed31719873

2017

Tethered Jagged-1 Synergizes with Culture Substrate Stiffness to Modulate Notch-Induced Myogenic Progenitor Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Helia Safaee,Mohsen A Bakooshli,Sadegh Davoudi,Richard Y Cheng,Aditya J Martowirogo,Edward W Li,Craig A Simmons,Penney M Gilbert

BMC research notes 10:358 PubMed28755659

2017

Authentication of collagen VI antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Jamie Endicott,Paul Holden,Jamie Fitzgerald
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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