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AB196613

Anti-Collagen XI alpha 2/COL11A2 antibody

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(1 Publication)

Rabbit Polyclonal Collagen XI alpha 2/COL11A2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Collagen alpha-2(XI) chain.

View Alternative Names

Collagen alpha-2(XI) chain, COL11A2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen XI alpha 2/COL11A2 antibody (AB196613)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen XI alpha 2/COL11A2 antibody (AB196613)

Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling Collagen XI alpha 2/COL11A2 using ab196613 at a 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Collagen alpha-2(XI) chain. The exact immunogen used to generate this antibody is proprietary information.

P13942

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Collagen XI alpha 2 (COL11A2) also known as alpha-2 chain of type XI collagen plays a mechanical role in the formation of collagen fibrils found in cartilage. This protein has a mass of approximately 178 kDa. COL11A2 is expressed in cartilaginous tissues including articular cartilage and intervertebral discs. Its structural properties help in maintaining the tensile strength and integrity of extracellular matrices in these tissues contributing to skeletal development and joint function.
Biological function summary

Collagen XI alpha 2 is integral to the development and maintenance of cartilage tissue. It is a component of the collagen type XI complex which includes collagen fibers composed of three polypeptide chains: alpha-1 alpha-2 and alpha-3. These fibers regulate the size and spacing of collagen fibrils during cartilage formation ensuring proper bone growth and maintenance. COL11A2 works in coordination with other collagen types such as collagen II and IX to ensure stability and structural cohesion within the cartilage matrix.

Pathways

Collagen XI alpha 2 is essential in the assembly and organization of collagen fibrils within the extracellular matrix which plays a vital role in the bone morphogenetic protein (BMP) signaling pathway and the TGF-beta (transforming growth factor-beta) pathway. These pathways facilitate various cellular processes including cell proliferation and differentiation. COL11A2 interacts with proteins like collagen type II (COL2A1) to modulate these pathways ensuring proper cartilage and skeletal tissue development.

COL11A2 mutations can lead to conditions such as Stickler syndrome and Otospondylomegapiphyseal Dysplasia (OSMED). Stickler syndrome affects connective tissues leading to abnormalities in the eyes bones and ears while OSMED results in skeletal dysplasia. Both disorders relate to structural anomalies in cartilage. The protein shares a linkage with collagen type II in these conditions as alterations in the COL11A2 gene can disrupt the normal interaction between these collagen molecules further impacting skeletal growth and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
See full target information Collagen alpha-2(XI) chain
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 10:1486 PubMed31920668

2019

Thalidomide Prevented and Ameliorated Pathogenesis of Crohn's Disease in Mice Regulation of Inflammatory Response and Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Hongjin Chen,Haixia Xu,Lijiao Luo,Lichao Qiao,Yaohui Wang,Minmin Xu,Youran Li,Ping Zhu,Bolin Yang
View all publications
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