Anti-COMMD7 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

COMMD7 plays a role in controlling inflammation and oxidative stress. It interacts with other COMMD family members forming a complex that influences NF-κB signaling pathways. This pathway is important for immune response regulation making COMMD7 critical for managing immune system activities and processes. By regulating NF-κB COMMD7 also contributes to the cell's response to stress and modulates inflammatory cytokine production impacting systemic inflammation levels.

Pathways

COMMD7 functions in the NF-κB and HIF-1α signaling pathways both important for cellular stress responses. These pathways control transcriptional programs linked to inflammation immunity and adaptive responses to low oxygen environments. COMMD7's interactions with IκB proteins and HIF-1α demonstrate its involvement in pathway regulation wherein it assists in managing the stability and activity of these proteins during cellular adaptation to environmental changes.