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AB300556

Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free)

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Rabbit Recombinant Monoclonal COMP/Cartilage oligomeric matrix protein antibody. Carrier free. Suitable for WB, IHC-P, IHC-Fr, IP and reacts with Human, Mouse, Rat samples.

View Alternative Names

Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5

13 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation.

Immunohistochemical analysis of paraffin-embedded Human skeletal muscle tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/2000 (0.246 ug/ml) followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used. Positive staining on human skeletal muscle (PMID : 19808781). The section was incubated with ab300555 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used.

Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution2) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation.

Immunohistochemical analysis of paraffin-embedded Human liver tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/2000 (0.246 ug/ml) followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used. Negative control : no staining on human liver (PMID : 14748877). The section was incubated with ab300555 for 30 mins at room temperature.The immunostaining was performed on a Leica Biosystems BOND® RX instrument Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used.

Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution2) for 20 mins.

Immunoprecipitation - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IP

Supplier Data

Immunoprecipitation - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. COMP/Cartilage oligomeric matrix protein was immunoprecipitated from 0.35 mg Human skeletal muscle tissue 10 ug with ab300555 at 1/30 dilution (2ug in 0.35mg lysates). Western blot was performed on the immunoprecipitate using ab300555 at 1/1000 dilution. Blocking and dilution buffer and concentration : 5% NFDM/TBST.

All lanes:

Immunoprecipitation - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (<a href='/en-us/products/primary-antibodies/comp-cartilage-oligomeric-matrix-protein-antibody-epr25364-6-ab300555'>ab300555</a>) at 1/1000 dilution

Lanes 1 - 2:

Human skeletal muscle tissue lysate

Lane 3:

Rabbit monoclonal IgG (<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a>) instead of <a href='/en-us/products/primary-antibodies/comp-cartilage-oligomeric-matrix-protein-antibody-epr25364-6-ab300555'>ab300555</a> in Human skeletal muscle tissue lysate

Secondary

All lanes:

Immunoprecipitation - VeriBlot for IP Detection Reagent (HRP) (<a href='/en-us/products/reagents/veriblot-for-ip-detection-reagent-hrp-ab131366'>ab131366</a>) at 1/5000 dilution

false

Exposure time: 76s

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation.

Immunohistochemical analysis of paraffin-embedded Mouse skeletal muscle tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/2000 (0.246 ug/ml) followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used. Positive staining on mouse skeletal muscle (PMID : 19808781). The section was incubated with ab300555 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used.

Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution2) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. Immunohistochemical analysis of paraffin-embedded Mouse cartilage tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/2000 (0.246 ug/ml) followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used. Positive staining on mouse cartilage (PMID : 33668140, PMID : 16542502 ).The section was incubated with ab300555 for 30 mins at room temperature.The immunostaining was performed on a Leica Biosystems BOND® RX instrument Counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution2) for 20 mins

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation.

Immunohistochemical analysis of paraffin-embedded Mouse liver tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/2000 (0.246 ug/ml) followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used. Negative control : no staining on mouse liver (PMID : 14748877). The section was incubated with ab300555 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection) was used.

Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution2) for 20 mins.

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. Immunohistochemical analysis of 4% PFA-fixed, 0.2% Triton X-100 permeabilized frozen Rat P0 articular cartilage (fresh) tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/500 (0.982 ug/ml) dilution followed by ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed at 1/1000 2 ug/mL dilution (Green). Positive staining on rat P0 articular cartilage is observed. The nuclear counterstain was DAPI (Blue). Secondary antibody control : Secondary antibody is ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbedat 1/1000 2 ug/mL dilution. .

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. Immunohistochemical analysis of 4% PFA-fixed, 0.2% Triton X-100 permeabilized frozen Rat liver (fresh) tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/500 (0.982 ug/ml) dilution followed by ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed at 1/1000 2 ug/mL dilution (Green). Negative control : no staining on rat liver (PMID : 14748877). is observed. The nuclear counterstain was DAPI (Blue). Secondary antibody control : Secondary antibody is ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbedat 1/1000 2 ug/mL dilution. .

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. Immunohistochemical analysis of 4% PFA-fixed, 0.2% Triton X-100 permeabilized frozen Mouse liver (fresh) tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/500 (0.982 ug/ml) dilution followed by ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed at 1/1000 2 ug/mL dilution (Green). Negative control : no staining on mouse liver (PMID : 14748877). is observed. The nuclear counterstain was DAPI (Blue). Secondary antibody control : Secondary antibody is ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbedat 1/1000 2 ug/mL dilution. .

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. Immunohistochemical analysis of 4% PFA-fixed, 0.2% Triton X-100 permeabilized frozen Mouse P0 articular cartilage (fresh) tissue labeling COMP/Cartilage oligomeric matrix protein with ab300555 at 1/500 (0.982 ug/ml) dilution followed by ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed at 1/1000 2 ug/mL dilution (Green). Positive staining on mouse P0 articular cartilage is observed. The nuclear counterstain was DAPI (Blue). Secondary antibody control : Secondary antibody is ab150081 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbedat 1/1000 2 ug/mL dilution. .

Immunoprecipitation - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • IP

Supplier Data

Immunoprecipitation - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. COMP/Cartilage oligomeric matrix protein was immunoprecipitated from 0.35 mg Mouse articular cartilage tissue lysate 10 ug with ab300555 at 1/30 dilution (2ug in 0.35mg lysates). Western blot was performed on the immunoprecipitate using ab300555 at 1/1000 dilution. Blocking and dilution buffer and concentration : 5% NFDM/TBST.

All lanes:

Immunoprecipitation - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (<a href='/en-us/products/primary-antibodies/comp-cartilage-oligomeric-matrix-protein-antibody-epr25364-6-ab300555'>ab300555</a>) at 1/1000 dilution

Lanes 1 - 2:

Mouse articular cartilage tissue lysate

Lane 3:

Rabbit monoclonal IgG (<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a>) instead of <a href='/en-us/products/primary-antibodies/comp-cartilage-oligomeric-matrix-protein-antibody-epr25364-6-ab300555'>ab300555</a> in mouse articular cartilage tissue lysate

Secondary

All lanes:

Immunoprecipitation - VeriBlot for IP Detection Reagent (HRP) (<a href='/en-us/products/reagents/veriblot-for-ip-detection-reagent-hrp-ab131366'>ab131366</a>) at 1/5000 dilution

false

Exposure time: 6s

Western blot - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • WB

Supplier Data

Western blot - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. The expression profile and molecular weight observed are consistent with what has been described in the literature (PMID : 24917676). The band at 82 KDa likely represents the unglycosylated form of the COMP monomer (PMID : 9143347). Blocking Buffer and concentration : 5% NFDM/TBST

All lanes:

Western blot - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (<a href='/en-us/products/primary-antibodies/comp-cartilage-oligomeric-matrix-protein-antibody-epr25364-6-ab300555'>ab300555</a>) at 1/5000 dilution

All lanes:

Human articar cartilage tissue lysate 20

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/10000 dilution

Observed band size: 100 kDa,82 kDa

false

Exposure time: 15s

Western blot - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)
  • WB

Supplier Data

Western blot - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (BSA and Azide free) (AB300556)

This data was developed using ab300555, the same antibody clone in a different buffer formulation. The expression profile and molecular weight observed are consistent with what has been described in the literature (PMID : 24917676). The band at 82 KDa likely represents the unglycosylated form of the COMP monomer (PMID : 9143347). Negative control : liver (PMID : 14748877) Blocking Buffer and concentration : 5% NFDM/TBST

All lanes:

Western blot - Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6] (<a href='/en-us/products/primary-antibodies/comp-cartilage-oligomeric-matrix-protein-antibody-epr25364-6-ab300555'>ab300555</a>) at 1/1000 dilution

Lane 1:

Mouse articar cartilage tissue lysate 20

Lane 2:

Mouse liver tissue lysate

Lane 3:

Rat articar cartilage tissue lysate 20

Lane 4:

Rat liver tissue lysate

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/50000 dilution

Observed band size: 100 kDa,82 kDa

false

Exposure time: 15s

  • Unconjugated

    Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-COMP/Cartilage oligomeric matrix protein antibody [EPR25364-6]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR25364-6

Isotype

IgG

Carrier free

Yes

Reacts with

Human, Mouse, Rat

Applications

IHC-P, IP, WB, IHC-Fr

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<p></p>", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Not Applicable.</p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Not Applicable.</p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Cartilage Oligomeric Matrix Protein (COMP) also known as oligomeric protein or COMP cartilage protein is a structural component found in the extracellular matrix of cartilage tissues. This matrix protein has a mass of approximately 524 kDa and is predominantly expressed in cartilage particularly hyaline cartilage. COMP forms pentameric structures which make it an important supporting element in the stability and resilience of cartilage. Researchers often use techniques like COMP ELISA to quantify its levels in biological samples.
Biological function summary

COMP interacts with other extracellular matrix components to enhance structural integrity and function of cartilage tissue. It performs significant roles in the organization and maintenance of the matrix tethering fibrillar proteins and supporting cellular interaction. COMP is not typically part of a large complex but works closely with collagens and other matrix proteins to form a robust and flexible extracellular environment.

Pathways

COMP participates in pathways associated with cartilage formation and turnover. It engages in chondrocyte-mediated processes that are vital for endochondral ossification and cartilage repair. Within these pathways it interacts with proteins such as collagen type II and decorin which facilitate the organization and mineralization of cartilage matrix. These interactions highlight the protein's importance in maintaining cartilage architecture and function.

COMP plays a role in chondrodysplasias and osteoarthritis. Mutations in the COMP gene can lead to skeletal disorders like pseudoachondroplasia and multiple epiphyseal dysplasia causing growth and developmental anomalies. In osteoarthritis alterations in COMP levels may serve as an indicator of cartilage degradation. COMP's relationships with proteins like aggrecan and matrilin-3 in these contexts highlight its involvement in pathologies that affect cartilage structure and health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors (PubMed : 16051604, PubMed : 16542502). Could play a role in the pathogenesis of osteoarthritis (PubMed : 16542502). Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (PubMed : 17993464). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
See full target information COMP
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com