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Mouse Monoclonal NDUFS8 antibody. Suitable for WB and reacts with Rat, Cow, Mouse, Human samples. Cited in 15 publications.

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Images

Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11] (AB110245), expandable thumbnail

Publications

Key facts

Isotype
IgG1
Host species
Mouse
Storage buffer

pH: 7.5
Preservative: 0.02% Sodium azide
Constituents: HEPES buffered saline

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Tested
Rat
Tested
Cow
Tested

Tested
Tested

Species
Rat
Dilution info
1 µg/mL
Notes

-

Species
Cow
Dilution info
1 µg/mL
Notes

-

Species
Mouse
Dilution info
1 µg/mL
Notes

-

Species
Human
Dilution info
1 µg/mL
Notes

-

Alternative names

Recommended products

Mouse Monoclonal NDUFS8 antibody. Suitable for WB and reacts with Rat, Cow, Mouse, Human samples. Cited in 15 publications.

Key facts

Isotype
IgG1
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
17C8E4E11
Light chain type
kappa
Concentration
Loading...
Purification notes

ab110245 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze

Notes

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The Complex I subunit 8 kDa also known as NDUFS8 or by its approximate mass of 8 kilodaltons (kDa) forms an integral part of the mitochondrial membrane. This protein is expressed in almost all human tissues reflecting its widespread cellular importance. As a subunit of NADH:ubiquinone oxidoreductase (Complex I) it contributes to the electron transport chain in mitochondria where it plays a mechanical role in electron transfer.

Biological function summary

Complex I subunit 8 kDa is involved in energy production within cells. As a component of Complex I it participates in the process of oxidative phosphorylation. This protein associates with other subunits to drive the transfer of electrons from NADH to ubiquinone which generates a proton gradient used by ATP synthase to produce ATP the energy currency of the cell.

Pathways

Complex I subunit 8 kDa is part of the mitochondrial respiratory chain especially influencing oxidative phosphorylation and energy metabolism pathways. It connects with other proteins such as NADH dehydrogenase and ubiquinone through these pathways. This connection emphasizes its central place in energy generation maintaining cellular metabolism and influencing the greater metabolic network.

Associated diseases and disorders

Complex I subunit 8 kDa plays a role in mitochondrial complex I deficiency and Leigh syndrome. These conditions exhibit its importance where dysfunction or mutation leads to issues in cellular energy processes. In the context of these disorders its relationship with other Complex I proteins highlights its interdependence with the mitochondrial machinery affecting energy production significantly when compromised.

Product promise

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1 product image

  • Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11] (ab110245), expandable thumbnail

    Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11] (ab110245)

    All lanes: Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11] (ab110245) at 1 µg/mL

    Lane 1: Human heart mitochondria at 10 µg

    Lane 2: Bovine heart mitochondria at 4 µg

    Lane 3: Rat heart mitochondria at 10 µg

    Lane 4: Mouse heart mitochondria at 10 µg

    Predicted band size: 24 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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