Anti-Complex II Immunocapture antibody [4H12BG12AG2]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Complex II also known as succinate dehydrogenase (SDH) is an important enzyme in the mitochondrial electron transport chain. It plays a central role in cellular respiration by enabling the oxidation of succinate to fumarate while simultaneously transferring electrons to ubiquinone. Complex II weighs approximately 124 kDa and consists of four subunits: SDHA SDHB SDHC and SDHD. It is located on the inner mitochondrial membrane and is widely expressed in various tissues reflecting its fundamental role in energy metabolism.

Biological function summary

Complex II is integral to both the citric acid cycle and the electron transport chain. It acts as a bridge linking these two metabolic pathways. As part of this dual association Complex II helps maintain mitochondrial respiratory efficiency. Unlike other complexes it does not directly pump protons across the mitochondrial membrane; instead it focuses on electron transfer. This specific function highlights its importance in cellular energy metabolism.

Pathways

Complex II contributes to the tricarboxylic acid cycle (TCA cycle) and the oxidative phosphorylation pathway. These pathways are important for ATP production within cells. Complex II's relationship with proteins such as ubiquinone and cytochrome c highlights its role in electron transfer efficiency. As electrons pass through Complex II they are directed towards further complexes in the electron transport chain ultimately leading to energy production.

Associated diseases and disorders

Mutations in Complex II subunits have been linked to disorders like paraganglioma and Leigh syndrome. These conditions often involve a disruption in energy metabolism within cells. The malfunction of related proteins like fumarase and other complexes can lead to a build-up of metabolites that result in pathogenesis. Understanding the function and regulation of Complex II can therefore provide insights into these mitochondrial diseases.