Anti-Connexin 40.1 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Gap junctions formed by Connexin 40.1 are essential for maintaining synchronized cardiac conduction. Connexin 40.1 interacts with other connexins to form heteromeric and heterotypic channels enhancing the complexity and selectivity of gap junctions. These channels participate in the propagation of action potentials across myocardial tissue contributing to rhythmic heart contractions. As part of these junctions Connexin 40.1 helps maintain cardiac stability and is pivotal in electrochemical coupling within the heart.

Pathways

Connexin 40.1 plays a role in the cardiac conduction system and the vasomotor regulation pathway. The protein cooperates closely with Connexin 43 and other connexins facilitating the propagation of electrical signals that drive myocardial contraction. In the heart Connexin 40.1 is part of the pathway responsible for facilitating atrial conduction ensuring efficient atrial impulse propagation. In vascular tissues it influences vasomotor tone by supporting cell communication necessary for smooth muscle contraction and relaxation.