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AB191285

Anti-Contactin 1 antibody

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(2 Publications)

Goat Polyclonal Contactin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CNTN1 aa 300-350.

View Alternative Names

Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Contactin 1 antibody (AB191285)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Contactin 1 antibody (AB191285)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain cerebellum tissue labeling Contactin 1 with ab191285 at 5 μg/ml.

Western blot - Anti-Contactin 1 antibody (AB191285)
  • WB

Supplier Data

Western blot - Anti-Contactin 1 antibody (AB191285)

The observed molecular weight corresponds to the glycosylated form.

All lanes:

Western blot - Anti-Contactin 1 antibody (ab191285) at 0.3 µg/mL

Lane 1:

Human cerebellum tissue lysate in RIPA buffer at 35 µg

Lane 2:

Mouse brain tissue lysate in RIPA buffer at 35 µg

Lane 3:

Rat brain tissue lysate in RIPA buffer

Predicted band size: 113 kDa

false

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CNTN1 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.

Q12860

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Contactin 1 also known as contactin-1 or contactin is a protein involved in cell adhesion processes. It is sometimes referred to as contacton. This protein has a molecular weight of approximately 120 kDa and is a neural membrane glycoprotein. Contactin 1 primarily expresses in the developing nervous system and persists in the adult central nervous system. It plays an important role in forming connections between neurons and ensuring proper communication between them.
Biological function summary

The role of this protein involves maintaining neuronal network organization and integrity. Contactin 1 plays a critical part in myelination a process essential for the swift conduction of nerve impulses. It interacts with several partners forming complexes essential for neuronal stability including neurofascin and contactin-associated protein-like 2. These interactions facilitate proper signal transmission across synapses in the nervous system.

Pathways

Contactin 1 is an important element in the pathways that regulate neuronal development and myelination. It is involved in the formation of the nodes of Ranvier important for nerve impulse transmission. Contactin 1 interacts with proteins such as tenascin-R and NrCAM in these processes contributing significantly to the formation and maintenance of functional neural networks.

Defects in the regulation or expression of contactin 1 are associated with neurological conditions like multiple sclerosis and Guillain-Barré syndrome. These disorders highlight problems in nerve signal transmission and immune system misregulation. Through these diseases contactin 1's interaction with proteins such as CASPR (contactin-associated protein-like 2) becomes important as disruptions in these interactions can lead to neuronal dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
See full target information CNTN1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Neurology(R) neuroimmunology & neuroinflammation 9: PubMed35314491

2022

Diabetes Mellitus Is a Possible Risk Factor for Nodo-paranodopathy With Antiparanodal Autoantibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Luise Appeltshauser,Julia Messinger,Katharina Starz,David Heinrich,Anna-Michelle Brunder,Helena Stengel,Bianca Fiebig,Ilya Ayzenberg,Frank Birklein,Christian Dresel,Johannes Dorst,Florian Dvorak,Alexander Grimm,Alexander Joerk,Frank Leypoldt,Mathias Mäurer,Patrick Merl,Sebastian Michels,Kalliopi Pitarokoili,Mathias Rosenfeldt,Anne-Dorte Sperfeld,Marc Weihrauch,Gabriel Simon Welte,Claudia Sommer,Kathrin Doppler

Molecules (Basel, Switzerland) 27: PubMed35268795

2022

Improved Wound Healing by Naringin Associated with MMP and the VEGF Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Hau Yen,Wan-Ting Chio,Chia-Ju Chuang,Hsin-Ling Yang,Sheng-Teng Huang
View all publications
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