Goat Polyclonal Contactin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CNTN1 aa 300-350.
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Publications
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- Neurology(R) neuroimmunology & neuroinflammation 9:2022Diabetes Mellitus Is a Possible Risk Factor for Nodo-paranodopathy With Antiparanodal Autoantibodies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLuise Appeltshauser,Julia Messinger,Katharina Starz,David Heinrich,Anna-Michelle Brunder,Helena Stengel,Bianca Fiebig,Ilya Ayzenberg,Frank Birklein,Christian Dresel,Johannes Dorst,Florian Dvorak,Alexander Grimm,Alexander Joerk,Frank Leypoldt,Mathias Mäurer,Patrick Merl,Sebastian Michels,Kalliopi Pitarokoili,Mathias Rosenfeldt,Anne-Dorte Sperfeld,Marc Weihrauch,Gabriel Simon Welte,Claudia Sommer,Kathrin DopplerPubMed 35314491
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human CNTN1 aa 300-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q12860
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Tested | Expected |
| Rat | Tested | Expected |
| Chimpanzee | Predicted | Predicted |
| Cow | Predicted | Predicted |
| Gorilla | Predicted | Predicted |
| Guinea pig | Predicted | Predicted |
| Monkey | Predicted | Predicted |
| Pig | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 0.30000-1.00000 µg/mL | Notes - |
Species Rat | Dilution info 0.30000-1.00000 µg/mL | Notes - |
Species Human | Dilution info 0.30000-1.00000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Guinea pig, Cow, Pig, Chimpanzee, Monkey, Gorilla | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Guinea pig, Cow, Pig, Chimpanzee, Monkey, Gorilla | Dilution info - | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Alternative names
Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1
Recommended products
Goat Polyclonal Contactin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CNTN1 aa 300-350.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human CNTN1 aa 300-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q12860
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Contactin 1 also known as contactin-1 or contactin is a protein involved in cell adhesion processes. It is sometimes referred to as contacton. This protein has a molecular weight of approximately 120 kDa and is a neural membrane glycoprotein. Contactin 1 primarily expresses in the developing nervous system and persists in the adult central nervous system. It plays an important role in forming connections between neurons and ensuring proper communication between them.
- Biological function summary
The role of this protein involves maintaining neuronal network organization and integrity. Contactin 1 plays a critical part in myelination a process essential for the swift conduction of nerve impulses. It interacts with several partners forming complexes essential for neuronal stability including neurofascin and contactin-associated protein-like 2. These interactions facilitate proper signal transmission across synapses in the nervous system.
- Pathways
Contactin 1 is an important element in the pathways that regulate neuronal development and myelination. It is involved in the formation of the nodes of Ranvier important for nerve impulse transmission. Contactin 1 interacts with proteins such as tenascin-R and NrCAM in these processes contributing significantly to the formation and maintenance of functional neural networks.
- Associated diseases and disorders
Defects in the regulation or expression of contactin 1 are associated with neurological conditions like multiple sclerosis and Guillain-Barré syndrome. These disorders highlight problems in nerve signal transmission and immune system misregulation. Through these diseases contactin 1's interaction with proteins such as CASPR (contactin-associated protein-like 2) becomes important as disruptions in these interactions can lead to neuronal dysfunction.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Contactin 1 antibody (ab191285)
Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain cerebellum tissue labeling Contactin 1 with ab191285 at 5 μg/ml.
Western blot - Anti-Contactin 1 antibody (ab191285)
The observed molecular weight corresponds to the glycosylated form.
All lanes: Western blot - Anti-Contactin 1 antibody (ab191285) at 0.3 µg/mL
Lane 1: Human cerebellum tissue lysate in RIPA buffer at 35 µg
Lane 2: Mouse brain tissue lysate in RIPA buffer at 35 µg
Lane 3: Rat brain tissue lysate in RIPA buffer
Predicted band size: 113 kDa
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