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AB251902

Anti-COPS6 antibody

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(1 Publication)

Rabbit Polyclonal COPS6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human COPS6 aa 200 to C-terminus.

View Alternative Names

CSN6, HVIP, COPS6, COP9 signalosome complex subunit 6, SGN6, Signalosome subunit 6, JAB1-containing signalosome subunit 6, MOV34 homolog, Vpr-interacting protein, hVIP

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-COPS6 antibody (AB251902)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-COPS6 antibody (AB251902)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for COPS6 (green) using ab251902 at 4 µg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPS6 antibody (AB251902)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPS6 antibody (AB251902)

Paraffin-embedded human stomach, lower tissue stained for COPS6 using ab251902 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human COPS6 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q7L5N1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Xenopus tropicalis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The COPS6 also known as COP9 signalosome complex subunit 6 is a component of the COP9 signalosome (CSN) complex. It has a molecular weight of approximately 33 kDa. This protein exists mostly in the nucleus and cytoplasm of cells. COPS6 helps regulate protein degradation by participating in deneddylase activity which is important for controlling the activity and stability of proteins targeted by the ubiquitin-proteasome system.
Biological function summary

COPS6 plays a role in several cellular functions beyond deneddylation. It is an integral part of the COP9 signalosome complex which modulates protein levels and activities by regulating the neddylation state of cullins. This regulation influences processes such as signal transduction and cell cycle control. The complex influences not just protein degradation but also various other cellular mechanisms through its wide interactions.

Pathways

COPS6 participates in the ubiquitin-mediated proteolysis pathway impacting the regulation of proteasome activities. Another significant pathway involving COPS6 is the cell cycle regulation pathway where it interacts with proteins like SKP1 and CUL1. These interactions highlight the significance of COPS6 in the coordination of cellular progression and responses to external signals facilitating proper cell function and survival.

COPS6 has connections to certain cancers and inflammatory diseases. Abnormal expression or mutations of COPS6 can lead to unregulated protein turnover contributing to oncogenesis in various tissues. It demonstrates interaction with proteins such as MDM2 which can influence tumor suppressor pathways. In inflammation maladjustment of proteasome activity involving COPS6 can exacerbate conditions by affecting inflammatory signaling cascades.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets.
See full target information COPS6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell transplantation 31:9636897221079336 PubMed35416722

2022

β-Asarone Protects PC12 Cells Against Hypoxia-Induced Injury Via Negatively Regulating RPPH1/MiR-542-3p/DEDD2 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Yang,Hongyu Duan,Nannan Ye,Yu Zeng,Pengxiang Yang,Bo Shao,Chunyu Wang,Gaojun Lin
View all publications
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