Rabbit Polyclonal COPT2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC31A2 aa 1-100.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SLC31A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link O15432
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes - |
Target data
Function
Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity).
Alternative names
COPT2, CTR2, SLC31A2, Protein SLC31A2, Copper transporter 2, Solute carrier family 31 member 2, hCTR2
Recommended products
Rabbit Polyclonal COPT2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC31A2 aa 1-100.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SLC31A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link O15432
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
Purity greater than 95%.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
COPT2 also known as COPTI or Copper Transporter 2 functions mechanically as a transporter protein responsible for moving copper ions across cell membranes. It facilitates the import of essential copper ions into the cells integral for various cellular processes. The mass of COPT2 is approximately 27 kilodaltons. It is mainly expressed in the liver kidneys and brain where cells demand efficient copper ion regulation.
- Biological function summary
COPT2 plays an important role in maintaining copper homeostasis within the body allowing proper cellular functions that require copper-dependent enzymes. COPT2 is not part of a protein complex but its significance lies in its singular ability to enhance cellular uptake of copper ions. Copper-dependent enzymes such as cytochrome c oxidase and superoxide dismutase rely on COPT2's function to maintain optimal activity within the cell.
- Pathways
COPT2 is directly involved in the copper regulation pathway ensuring that cells receive sufficient copper ions for enzymatic activities. This pathway also interacts with metallothioneins which are proteins responsible for metal detoxification and storage. COPT2's function complements other copper transport proteins like ATP7A and ATP7B which help in exporting and distributing copper within the body.
- Associated diseases and disorders
Disturbances in COPT2 function contribute to conditions such as Wilson's disease and Menkes disease. Wilson's disease results from copper accumulation due to impaired copper transport while Menkes disease involves defective copper absorption. COPT2 works alongside proteins like ATP7B in Wilson's disease and ATP7A in Menkes disease highlighting its important involvement in managing copper ion levels and maintaining cellular health.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunocytochemistry/ Immunofluorescence - Anti-COPT2 antibody (ab238911)
HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for COPT2 (Green) using ab238911 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (ab238911)
Paraffin-embedded human gastric cancer tissue stained for COPT2 using ab238911 at 1/100 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (ab238911)
Paraffin-embedded human prostate cancer tissue stained for COPT2 using ab238911 at 1/100 dilution in immunohistochemical analysis.
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