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AB238911

Anti-COPT2 antibody

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(1 Publication)

Rabbit Polyclonal COPT2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC31A2 aa 1-100.

View Alternative Names

COPT2, CTR2, SLC31A2, Protein SLC31A2, Copper transporter 2, Solute carrier family 31 member 2, hCTR2

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)

Paraffin-embedded human gastric cancer tissue stained for COPT2 using ab238911 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)

Paraffin-embedded human prostate cancer tissue stained for COPT2 using ab238911 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-COPT2 antibody (AB238911)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-COPT2 antibody (AB238911)

HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for COPT2 (Green) using ab238911 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLC31A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O15432

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COPT2 also known as COPTI or Copper Transporter 2 functions mechanically as a transporter protein responsible for moving copper ions across cell membranes. It facilitates the import of essential copper ions into the cells integral for various cellular processes. The mass of COPT2 is approximately 27 kilodaltons. It is mainly expressed in the liver kidneys and brain where cells demand efficient copper ion regulation.
Biological function summary

COPT2 plays an important role in maintaining copper homeostasis within the body allowing proper cellular functions that require copper-dependent enzymes. COPT2 is not part of a protein complex but its significance lies in its singular ability to enhance cellular uptake of copper ions. Copper-dependent enzymes such as cytochrome c oxidase and superoxide dismutase rely on COPT2's function to maintain optimal activity within the cell.

Pathways

COPT2 is directly involved in the copper regulation pathway ensuring that cells receive sufficient copper ions for enzymatic activities. This pathway also interacts with metallothioneins which are proteins responsible for metal detoxification and storage. COPT2's function complements other copper transport proteins like ATP7A and ATP7B which help in exporting and distributing copper within the body.

Disturbances in COPT2 function contribute to conditions such as Wilson's disease and Menkes disease. Wilson's disease results from copper accumulation due to impaired copper transport while Menkes disease involves defective copper absorption. COPT2 works alongside proteins like ATP7B in Wilson's disease and ATP7A in Menkes disease highlighting its important involvement in managing copper ion levels and maintaining cellular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed : 17617060, PubMed : 17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity).
See full target information SLC31A2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 20:1045-1063 PubMed38322121

2024

The homeoprotein HOXB2 limits triple-negative breast carcinogenesis via extracellular matrix remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hoon Oh,Clara Yuri Kim,Da Som Jeong,Yu Cheon Kim,Myoung Hee Kim,Je-Yoel Cho
View all publications
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Product promise

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