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AB236670

Anti-COPZ1 antibody

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(1 Publication)

Rabbit Polyclonal COPZ1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human COPZ1.

View Alternative Names

COPZ, CGI-120, HSPC181, COPZ1, Coatomer subunit zeta-1, Zeta-1-coat protein, Zeta-1 COP

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPZ1 antibody (AB236670)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPZ1 antibody (AB236670)

Paraffin-embedded human brain tissue stained for COPZ1 using ab236670 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPZ1 antibody (AB236670)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPZ1 antibody (AB236670)

Paraffin-embedded human cervical cancer tissue stained for COPZ1 using ab236670 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human COPZ1.

P61923

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Proteins & Peptides

AB107148

Recombinant Human COPZ1 protein (His tag N-Terminus)

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Primary Antibodies

AB16056

Anti-COX IV antibody - Mitochondrial Loading Control

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COPZ1 also known as coatomer subunit zeta-1 is a protein subunit of the coatomer complex involved in forming the COPI vesicles which are important for transport in cellular processes. This protein has a molecular mass of about 19.1 kDa. COPZ1 is expressed in various tissues with higher expression observed in certain epithelial tissues. It facilitates the proliferation and maintenance of the Golgi apparatus by participating in retrograde Golgi-to-ER transport.
Biological function summary

COPZ1 is part of the coatomer protein complex which is essential for vesicular trafficking. The complex plays an important role in maintaining Golgi structure and function by recycling proteins back to the endoplasmic reticulum. COPZ1 functions within this complex to ensure that cellular components are transported effectively influencing secretion and cell surface receptor cycling processes.

Pathways

COPZ1 takes part in intracellular trafficking networks specifically the COPI-mediated transport pathway. This pathway includes coatomer protein complexes like COPB1 and COPB2 which work alongside COPZ1. It is involved with the retrograde transport of proteins from the Golgi to the ER impacting overall cellular homeostasis and secretion pathways.

COPZ1 has connections to cancer cell proliferation processes. Its expression levels can affect tumor growth and it is linked to certain cancer types such as breast cancer. COPZ1's interaction with proteins like ARF1 which influences vesicle formation plays a role in oncogenic pathways by potentially altering cellular motility and invasiveness in tumor environments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
See full target information COPZ1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 15:1531420 PubMed40519291

2025

Metformin inhibits the proliferation of hepatocellular carcinoma cells through inducing ferroptosis analyzed by phosphoproteomics.

Applications

Unspecified application

Species

Unspecified reactive species

Jihan Sun,Xi Yu,Yuying Shan,Manyun Dai,Andrea Gaucherot,Caide Lu,Shuqi Mao
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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