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AB220914

Anti-COQ2 antibody

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(1 Publication)

Rabbit Polyclonal COQ2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human COQ2 aa 250-350.

View Alternative Names

CL640, COQ2, 4-HB polyprenyltransferase, 4-hydroxybenzoate decaprenyltransferase, COQ2 homolog, Para-hydroxybenzoate--polyprenyltransferase, hCOQ2, PHB:PPT, PHB:polyprenyltransferase

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-COQ2 antibody (AB220914)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-COQ2 antibody (AB220914)

Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized A431 cells labeling COQ2 with ab220914 at 2 μg/ml (green).

Western blot - Anti-COQ2 antibody (AB220914)
  • WB

Supplier Data

Western blot - Anti-COQ2 antibody (AB220914)

Western blot analysis of CAPAN-2 cell lysate with ab220914 at 0.4 μg/ml.

All lanes:

Western blot - Anti-COQ2 antibody (ab220914) at 0.4 µg/mL

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human COQ2 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.

Q96H96

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COQ2 also known as PDSS1 is a protein involved in the biosynthesis of coenzyme Q10 (CoQ10) an important molecule in cellular energy production. COQ2 has a molecular weight of approximately 39 kDa and is expressed mainly in the mitochondria of most tissues with high levels in energy-demanding tissues like the heart kidneys and liver. COQ2 serves as a polyprenyl transferase enzyme facilitating the transfer of a polyprenyl group to para-hydroxybenzoate a critical step in the production of CoQ10.
Biological function summary

COQ2 plays a central role in producing CoQ10 a fundamental component of the mitochondrial electron transport chain. COQ2 is part of the larger CoQ biosynthetic complex which includes several other COQ proteins. These proteins work together to ensure the correct synthesis and regulation of CoQ10. This collective action helps maintain cellular energy homeostasis and protects against oxidative stress by scavenging free radicals.

Pathways

COQ2 is an essential player in the coenzyme Q biosynthesis pathway and more generally in the oxidative phosphorylation pathway. Interaction with other proteins such as COQ3 and COQ9 further enhances its function in these pathways. COQ2's contribution to the electron transport chain allows efficient ATP production essential for overall cellular metabolism.

Mutations in the COQ2 gene have been linked to CoQ10 deficiency manifesting as various clinical conditions like nephrotic syndrome and cerebellar ataxia. Altered COQ2 function may impact COQ8 another affinity protein within the coenzyme Q biosynthesis pathway aggravating these conditions due to compromised energy production in affected tissues. Understanding these associations aids in deciphering how COQ2 mutations contribute to mitochondrial-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed : 15153069, PubMed : 16400613, PubMed : 17374725, PubMed : 20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate) (PubMed : 15153069, PubMed : 16400613, PubMed : 17374725, PubMed : 20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls (decaprenyl) producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed : 15153069, PubMed : 16400613). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (PubMed : 15153069). Plays a central role in the biosynthesis of CoQ10 (PubMed : 15153069, PubMed : 16400613, PubMed : 17374725). CoQ10 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (PubMed : 16400613, PubMed : 17374725, PubMed : 27493029). CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway (PubMed : 16400613, PubMed : 17374725). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (By similarity).
See full target information COQ2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 21:350 PubMed37759249

2023

Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Song Qingxin,Jiang Kai,Zheng Dandan,Jin Linyu,Chen Xiuyuan,Feng Yubo,Wang Kun,Han Yingchao,Chen Hao,Song Jie,Chen Zhi,Shen Hongxing
View all publications
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