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AB313414

Anti-Corin antibody [RP23040188]

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Rabbit Recombinant Multiclonal CORIN antibody. Suitable for IHC-Fr, WB and reacts with Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human CORIN.

View Alternative Names

CRN, TMPRSS10, CORIN, Atrial natriuretic peptide-converting enzyme, Corin, Heart-specific serine proteinase ATC2, Pro-ANP-converting enzyme, Transmembrane protease serine 10

2 Images
Immunohistochemistry (Frozen sections) - Anti-Corin Antibody [RP23040188] (AB313414)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-Corin Antibody [RP23040188] (AB313414)

Immunofluorescent analysis of frozen rat heart tissue (atrium) fixed with 4% PFA for 20 min, permeabilized using 0.1% Triton X 100 for 10 mins and blocked for 1 hour with 2% BSA labeling Corin with ab313414 at 2 µg/mL dilution followed by Goat anti-Rabbit IgG (H+L) Secondary Antibody, Alexa Fluor® 488 conjugate at 1/2000 dilution. Nuclei (blue) were stained using DAPI, and cytoskeletal F-actin (red) was stained using Rhodamine Phalloidin at 1/300 dilution. Panel a) represents staining with the matched isotype control. Panel b) shows a representative section stained for Corin (green). The images were captured at 20X magnification.

Immunohistochemistry (Frozen sections) - Anti-Corin Antibody [RP23040188] (AB313414)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-Corin Antibody [RP23040188] (AB313414)

Immunofluorescent analysis of frozen mouse heart tissue fixed with 4% PFA for 20 min, permeabilized using 0.1% Triton X 100 for 10 mins and blocked for 1 hour with 2% BSA labeling Corin with ab313414 at 2 µg/mL dilution followed by Goat anti-Rabbit IgG (H+L) Secondary Antibody, Alexa Fluor® 488 conjugate at 1/2000 dilution. Nuclei (blue) were stained using DAPI, and cytoskeletal F-actin (red) was stained using Rhodamine Phalloidin at 1/300 dilution. Panel a) represents staining with the matched isotype control. Panel b) shows a representative section stained for Corin (green). The images were captured at 20X magnification.

Key facts

Host species

Rabbit

Clonality

Multiclonal

Clone number

RP23040188

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB, IHC-Fr

applications

Immunogen

Recombinant Fragment Protein within Human CORIN.

Q9Y5Q5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "2 µg/mL", "IHCFr-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "2 µg/mL", "IHCFr-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Product details

What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:

  • - The sensitivity of polyclonal antibodies by recognising multiple epitopes
  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

View our range of recombinant multiclonal antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed : 10880574, PubMed : 20489134, PubMed : 21288900, PubMed : 21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed : 10880574, PubMed : 20489134, PubMed : 21288900, PubMed : 21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed : 22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity).. Isoform 2. Has weaker endopeptidase activity compared to isoform 1.
See full target information CORIN
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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