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AB119714

Anti-CORO1B antibody

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(2 Publications)

Rabbit Polyclonal CORO1B antibody. Suitable for WB, ICC/IF and reacts with Human, Rabbit samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CORO1B.

View Alternative Names

Coronin-1B, Coronin-2, CORO1B

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-CORO1B antibody (AB119714)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CORO1B antibody (AB119714)

ab119714 at 1/100 dilution staining CORO1B in Rabbit spleen fibroblasts treated with Calyculin A in the absence (left) or presence (right) of blocking peptide. Detection used an appropriate secondary antibody conjugated to Cy3.

Western blot - Anti-CORO1B antibody (AB119714)
  • WB

Unknown

Western blot - Anti-CORO1B antibody (AB119714)

Lanes 1 - 2:

Western blot - Anti-CORO1B antibody (ab119714) at 1/1000 dilution

Lanes 3 - 4:

Anti-CORO1B (phospho S2) antibody (<a href='/en-us/products/unavailable/coro1b-phospho-s2-antibody-ab119705'>ab119705</a>) at 1/1000 dilution

Lanes 1 and 3:

Human A431 cells treated with Calyculin A (100 nM) for 30 min

Lanes 2 and 4:

Human A431 cells treated with Calyculin A (100 nM) for 30 min before treatment with lambda phosphatase

Predicted band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rabbit, Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human CORO1B. The exact immunogen used to generate this antibody is proprietary information.

Q9BR76

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Do not aliquot.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab119714 was affinity purified using CORO1B (C-terminus) peptide (without carrier).
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein CORO1B also known as Coronin-1B is an actin-binding protein involved in cellular structure and motility. CORO1B weighs approximately 55 kDa and is part of the coronin family. It is expressed in various tissues with strong expression in brain heart and skeletal muscle. Functionally CORO1B regulates actin cytoskeleton dynamics which is important for processes such as cell migration and maintenance of cell shape.
Biological function summary

Coronin-1B acts to control the remodeling of actin filaments. This protein plays a role in actin cytoskeleton organization and is located typically in cellular regions such as lamellipodia and filopodia. It acts independently but can also form complexes with other proteins like Arp2/3 complex to facilitate actin branching. Through its interactions Coronin-1B modulates the cell's cytoskeletal architecture impacting cell movement and adhesion.

Pathways

Studies connect Coronin-1B to the actin-related protein 2/3 (Arp2/3) complex pathway which influences actin polymerization. Coronin-1B also associates with the Rac1 pathway affecting cell migration and cellular responses to the environment. RAC1 a small GTPase involved in numerous cellular projects often associates with Coronin-1B in regulating actin dynamics. These pathways indicate its significant role in cellular movement and organization.

Studies link Coronin-1B to cancer metastasis due to its regulatory function in cell motility. Overexpression or mutation of Coronin-1B might influence cancer progression by altering cell migration patterns. Additionally Coronin-1B has connections to cardiovascular diseases where disruptions in actin dynamics affect heart muscle function. It often associations with other proteins like Arp2/3 and RAC1 which participate in related pathological processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
See full target information CORO1B
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 221: PubMed35802042

2022

Coronin 1C restricts endosomal branched actin to organize ER contact and endosome fission.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan F Striepen,Gia K Voeltz

Oncotarget 8:9067-9078 PubMed27391067

2016

A dose-dependent perturbation in cardiac energy metabolism is linked to radiation-induced ischemic heart disease in Mayak nuclear workers.

Applications

Unspecified application

Species

Unspecified reactive species

Omid Azimzadeh,Tamara Azizova,Juliane Merl-Pham,Vikram Subramanian,Mayur V Bakshi,Maria Moseeva,Olga Zubkova,Stefanie M Hauck,Nataša Anastasov,Michael J Atkinson,Soile Tapio
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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