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AB151327

Anti-CORO2B antibody

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(1 Publication)

Rabbit Polyclonal CORO2B antibody. Suitable for ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CORO2B aa 1-250.

View Alternative Names

KIAA0925, CORO2B, Coronin-2B, Coronin-like protein C, Protein FC96, Clipin-C

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CORO2B antibody (AB151327)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CORO2B antibody (AB151327)

Immunohistochemical analysis of paraffin-embedded H441 xenograft labeling CORO2B with ab151327 at 1/100 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-CORO2B antibody (AB151327)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CORO2B antibody (AB151327)

Immunofluorescent analysis of methanol-fixed MCF-7 cells labeling CORO2B with ab151327 at 1/200 dilution. Right panel co-stained with Hoechst 33342.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CORO2B aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9UQ03

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CORO2B also known as Coronin-2B is a protein with a mass of approximately 51 kDa. It belongs to the coronin family and is involved in cellular organization. CORO2B typically expresses in tissues with high concentrations of actin filaments such as neurons and muscle cells. It binds to actin and plays a role in various cellular dynamics processes.
Biological function summary

CORO2B associates with the regulation of cytoskeleton organization. It is part of the actin-binding complex and contributes to actin filament remodeling and stabilization. This protein interacts with other cytoskeletal proteins to modulate the structure and dynamics of the actin network impacting cell movement adhesion and morphology.

Pathways

CORO2B takes part in actin cytoskeleton regulation and the Wnt signaling pathway. It collaborates with other proteins like ARP2/3 complex and cofilin to influence actin filament dynamics. These pathways are essential for maintaining cellular architecture and transmitting signals that direct cell positioning and polarity.

CORO2B shows relevance to neurodegenerative diseases and cancer. Abnormal expression or mutation of CORO2B can disrupt cytoskeletal dynamics contributing to pathological conditions such as Alzheimer's disease. It also interacts with proteins like tau in neurodegenerative contexts and EGFR in cancer progression highlighting its involvement in disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the reorganization of neuronal actin structure.
See full target information CORO2B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 293:17769-17779 PubMed30282801

2018

Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Qi,Xiaoyan Shi,Miao Yu,Boya Liu,Minghui Liu,Shi Song,Shuaiyi Chen,Junhua Zou,Wei-Guo Zhu,Jianyuan Luo
View all publications
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Product promise

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