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AB68310

Anti-COSMC antibody

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Mouse Polyclonal COSMC antibody. Carrier free. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human C1GALT1C1.

View Alternative Names

COSMC, HSPC067, MSTP143, UNQ273/PRO310, C1GALT1C1, C1GALT1-specific chaperone 1, C38H2-like protein 1, Core 1 beta3-galactosyltransferase-specific molecular chaperone, C38H2-L1, C1Gal-T2, C1GalT2, Core 1 beta3-Gal-T2

2 Images
Western blot - Anti-COSMC antibody (AB68310)
  • WB

Unknown

Western blot - Anti-COSMC antibody (AB68310)

All lanes:

Western blot - Anti-COSMC antibody (ab68310) at 1/500 dilution

All lanes:

human liver tissue lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 36 kDa

Observed band size: 32 kDa

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Western blot - Anti-COSMC antibody (AB68310)
  • WB

Unknown

Western blot - Anti-COSMC antibody (AB68310)

All lanes:

Western blot - Anti-COSMC antibody (ab68310) at 1/500 dilution

Lane 1:

COSMC transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 36 kDa

Observed band size: 32 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human C1GALT1C1.

Q96EU7

Specificity

This antibody is reactive against mammalian transfected lysate.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COSMC also known as "core 1 β3-Gal-T-specific molecular chaperone" is a molecular chaperone that plays a significant role in the proper formation of glycoproteins. It has a mass of approximately 55 kDa and is primarily expressed in the endoplasmic reticulum (ER). COSMC assists in ensuring the stability and activity of the T-synthase enzyme which is important for the O-glycosylation process in cells.
Biological function summary

This target ensures accurate glycan biosynthesis by acting as a proper folding assistant for its enzyme partner T-synthase. As part of this functional duo COSMC does not operate alone but facilitates a complex where proper protein folding and expression are necessary. Without COSMC's guidance T-synthase becomes inactive resulting in improper glycosylation patterns that can affect cellular functionality and communication.

Pathways

COSMC-related activities are important in the O-glycan biosynthesis pathway which is important for the production of mucins and other glycoproteins involved in cell signaling and adhesion. This chaperone also interacts with proteins in the Golgi apparatus where it supports the biosynthetic pathway of type 1 and type 2 core structures. COSMC's interaction ensures accurate protein glycosylation which impacts several cellular processes.

Faulty COSMC function is linked to Tn syndrome where improper glycan synthesis leads to an accumulation of specific glycoprotein types that can disrupt normal cellular behavior. Aberrant glycan structures resulting from COSMC mutations also connect it to cancer progression as it relates to altered cell surface antigens. This protein's function or malfunction within these contexts highlights the potential connections with other proteins such as T-synthase in glycan-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).
See full target information C1GALT1C1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB229831

Anti-COSMC antibody

primary-antibodies

cosmc-antibody-ab229831

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(0 reviews)

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