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AB238902

Anti-COX11 antibody

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(1 Publication)

Rabbit Polyclonal COX11 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Cytochrome c oxidase assembly protein COX11, mitochondrial aa 100 to C-terminus.

View Alternative Names

COX11

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX11 antibody (AB238902)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX11 antibody (AB238902)

Paraffin-embedded human colon cancer tissue stained for COX11 using ab238902 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX11 antibody (AB238902)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX11 antibody (AB238902)

Paraffin-embedded human kidney tissue stained for COX11 using ab238902 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-COX11 antibody (AB238902)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-COX11 antibody (AB238902)

MCF7 (Human breast adenocarcinoma cell line) cells stained for COX11 (green) using ab238902 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa-Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Cytochrome c oxidase assembly protein COX11, mitochondrial aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6N1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COX11 also known as cytochrome c oxidase assembly protein COX11 plays a role in the transfer of copper to cytochrome c oxidase (COX) during its assembly. This protein does not form part of the final COX complex. Instead COX11 aids in the initial copper insertion required for COX function. It possesses a molecular mass of approximately 28 kDa. COX11 is expressed in mitochondria where it contributes to these copper-dependent processes.
Biological function summary

COX11 impacts cytochrome c oxidase complex formation by participating in essential copper delivery. This protein serves a non-redundant role in stabilizing COX structure. COX also known as Complex IV is part of the mitochondrial respiratory chain responsible for electron transport and ATP production. COX11's actions ensure efficient COX assembly and maintain the electron transport chain's integrity.

Pathways

COX11 influences mitochondrial electron transport which is key for cellular respiration and energy metabolism. The protein assists in the formation of the electron transport chain. COX11 shares pathways with proteins like COX10 another copper insertase involved in COX assembly contributing to the COX complex formation and stabilization.

COX11 dysfunction associates with mitochondrial disorders such as Leigh syndrome a severe neurological condition. Defects in COX11 may lead to improper COX assembly which disrupts energy production in cells. COX11 abnormalities are connected to mutations affecting the COX complex linking it to other proteins involved in mitochondrial disorders such as COX15.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
See full target information Cytochrome c oxidase assembly protein COX11, mitochondrial
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 20:1045-1063 PubMed38322121

2024

The homeoprotein HOXB2 limits triple-negative breast carcinogenesis via extracellular matrix remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hoon Oh,Clara Yuri Kim,Da Som Jeong,Yu Cheon Kim,Myoung Hee Kim,Je-Yoel Cho
View all publications
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Product promise

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