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AB131143

Anti-COX7A2 antibody

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(2 Publications)

Rabbit Polyclonal COX7A2 antibody. Suitable for IHC-P, WB and reacts with Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human COX7A2.

View Alternative Names

COX7AL, COX7A2, Cytochrome c oxidase subunit VIIa-liver/heart, Cytochrome c oxidase subunit VIIa-L, Cytochrome c oxidase subunit VIIaL

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX7A2 antibody (AB131143)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX7A2 antibody (AB131143)

Immunohistochemical analysis of paraffin-embedded Human heart tissue labelling COX7A2 with ab131143 at 1/50 dilution.

Western blot - Anti-COX7A2 antibody (AB131143)
  • WB

Unknown

Western blot - Anti-COX7A2 antibody (AB131143)

All lanes:

Western blot - Anti-COX7A2 antibody (ab131143) at 1/500 dilution

Lane 1:

Rat heart cell extract

Lane 2:

Rat heart cell extract with immunising peptide

Predicted band size: 11 kDa,13 kDa,48 kDa,68 kDa,76 kDa,78 kDa,9 kDa

Observed band size: 45 kDa,68 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human COX7A2. The exact immunogen used to generate this antibody is proprietary information.

P14406

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COX7A2 also known as cytochrome c oxidase subunit 7A2 is a component of the cytochrome c oxidase complex found in the inner mitochondrial membrane. This protein has an approximate molecular mass of 9.8 kDa. COX7A2 is expressed in various tissues with notable expression in highly metabolic tissues such as the heart and skeletal muscle. It plays a role in the electron transport chain by participating in the reduction of oxygen to water.
Biological function summary

COX7A2 contributes to the cytochrome c oxidase (complex IV) of the mitochondrial electron transport chain. This complex is important for ATP production through oxidative phosphorylation. COX7A2 forms part of the multi-subunit complex that facilitates efficient transfer of electrons which is essential for mitochondrial energy production. Its function in this complex underlines its importance in maintaining cellular respiration and energy homeostasis.

Pathways

COX7A2 plays an important role in the mitochondrial oxidative phosphorylation pathway. This pathway is essential for ATP production in eukaryotic cells. Another significant pathway involving COX7A2 is the respiratory electron transport pathway. Within these pathways COX7A2 interacts with other cytochrome c oxidase subunits like COX4 and COX5A which help regulate electron transfer and influence overall metabolic activity.

COX7A2 alterations and dysfunctions have been associated with mitochondrial disorders and myopathies. These disorders are often characterized by impaired energy metabolism due to defective oxidative phosphorylation. Within this context changes in COX7A2 expression can influence the functions of other cytochrome c oxidase subunits potentially affecting mitochondrial function and contributing to the pathological state of diseases like mitochondrial encephalomyopathy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
See full target information COX7A2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Functional & integrative genomics 25:90 PubMed40240625

2025

Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks.

Applications

Unspecified application

Species

Unspecified reactive species

Weina Lu,Yifeng Mao,Shangwen Cai,Qingqing Chen,Panpan Xu,Chenghua Xu,Cheng Zheng,Jian Lan

Glia 73:140-158 PubMed39392208

2024

The role of oligodendrocyte progenitor cells in the spatiotemporal vascularization of the human and mouse neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiyi Liu,Zhiruo Kang,Min Yang,Fangbing Chen,Mingyang Xia,Wenjuan Dai,Shiyi Zheng,Huiyao Chen,Q Richard Lu,Wenhao Zhou,Yifeng Lin
View all publications
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