JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB222129

Anti-COX7A2L antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal COX7A2L antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human COX7A2L aa 1-100.

View Alternative Names

COX7AR, COX7RP, SCAF1, SCAFI, COX7A2L, Cytochrome c oxidase subunit 7A-related protein, Cytochrome c oxidase subunit VIIa-related protein, EB1, Supercomplex assembly factor 1, COX7a-related protein

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-COX7A2L antibody (AB222129)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-COX7A2L antibody (AB222129)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for COX7A2L (green) using ab222129 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human COX7A2L aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O14548

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COX7A2L also known as Cytochrome c oxidase subunit 7A-related protein or COX7AR is an important component of the mitochondrial respiratory chain. It has an approximate mass of 12.4 kDa. This protein is primarily expressed in tissues with high-energy demands such as the heart brain and skeletal muscle. COX7A2L is a mitochondrial outer membrane protein that is involved in the function of the electron transport chain where it facilitates the efficient transfer of electrons.
Biological function summary

COX7A2L engages in processes beyond its individual capabilities as it is a part of the supercomplex known as the respirasome. It modulates the stability and arrangement of complexes I III and IV within the mitochondrial electron transport chain. This protein plays a role in ATP production by optimizing the efficiency of electron transfer and reducing the generation of reactive oxygen species. Through these mechanisms COX7A2L supports energy metabolism and cellular respiration.

Pathways

COX7A2L influences both the oxidative phosphorylation pathway and the mitochondrial apoptosis pathway. It interacts with proteins such as Cytochrome c and ATP synthase to maintain effective energy conversion and to regulate programmed cell death processes. The function of COX7A2L ensures proper mitochondrial respiration which is critical for cell survival and energy output.

COX7A2L has associations with metabolic and neurodegenerative diseases including MELAS syndrome and Parkinson's disease. Alterations in COX7A2L can disrupt normal mitochondrial function which leads to deficits in energy metabolism. This protein is also linked to Cytochrome c through its role in apoptosis highlighting its significance in the pathology of diseases where mitochondrial dysfunction is a factor.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism (PubMed : 27545886, PubMed : 30428348, PubMed : 33727070, PubMed : 36198313). Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association (PubMed : 27545886, PubMed : 36198313). Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV (PubMed : 27545886, PubMed : 30428348). Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV (By similarity). The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion : supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis (PubMed : 36198313).
See full target information COX7A2L
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

HGG advances 5:100353 PubMed39275801

2024

Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy.

Applications

Unspecified application

Species

Unspecified reactive species

John R Wells,Maria B Padua,Allison M Haaning,Amanda M Smith,Shaine A Morris,Muhammad Tariq,Stephanie M Ware

iScience 27:109164 PubMed38414856

2024

Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew Triolo,Nicole Baker,Soniya Agarwal,Nikita Larionov,Tina Podinić,Mireille Khacho
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB14705

Anti-MTCO1 antibody [1D6E1A8]

BOND RX™ Validated|Recombinant

Western blot - Anti-MTCO1 antibody [1D6E1A8] (AB14705)

  • 5
  • 44
Primary Antibodies

AB157457

Anti-OPA1 antibody [EPR11057(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OPA1 antibody [EPR11057(B)] (AB157457)

  • 4
  • 5
Primary Antibodies

AB14745

Anti-UQCRC2 antibody [13G12AF12BB11]

BOND RX™ Validated

Western blot - Anti-UQCRC2 antibody [13G12AF12BB11] (AB14745)

  • 5
  • 12
Primary Antibodies

AB110242

Anti-NDUFB8 antibody [20E9DH10C12]

Western blot - Anti-NDUFB8 antibody [20E9DH10C12] (AB110242)

  • 5
  • 5

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com